Dorsolateral prefrontal lobe activation declines significantly with age: Functional NIRS study

Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

41 Scopus citations


Dorsolateral prefrontal cortex (DLPF) activation in response to cognitive paradigms engaging working memory was quantitatively evaluated using functional near infrared spectroscopy (fNIRS) in cognitively normal individuals across the age spectrum (20-90 years; 8 females, 52 males). DLPF activation score (DAS) demonstrated a significant decline (r2 = -0561, p < 0.05) as a function of age. The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalJournal of Neurology
Issue number5
StatePublished - May 1 2003



  • Aging
  • DLPF
  • Dorsolateral prefrontal cortex
  • fNIRS
  • Functional MRI
  • Functional near infrared spectroscopy
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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