Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

Karmen K. Yoder, Gary D. Hutchins, Evan D. Morris, Allison Brashear, Chunzi Wang, Anantha Shekhar

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalSchizophrenia Research
Volume71
Issue number2-3
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • Caudate
  • Dopamine transporter
  • PANSS
  • Putamen
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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