Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Steven M. Graves, Zhong Xie, Kristen A. Stout, Enrico Zampese, Lena F. Burbulla, Jean C. Shih, Jyothisri Kondapalli, Tomasso Patriarchi, Lin Tian, Lars Brichta, Paul Greengard, Dimitri Krainc, Paul T. Schumacker, D. James Surmeier

Research output: Contribution to journalArticle

Abstract

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalNature Neuroscience
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2020

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Monoamine Oxidase
Electron Transport
Dopamine
Mitochondrial Membranes
Hydrogen Peroxide
Energy Metabolism
Electrons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., ... Surmeier, D. J. (2020). Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience, 23(1), 15-20. https://doi.org/10.1038/s41593-019-0556-3

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. / Graves, Steven M.; Xie, Zhong; Stout, Kristen A.; Zampese, Enrico; Burbulla, Lena F.; Shih, Jean C.; Kondapalli, Jyothisri; Patriarchi, Tomasso; Tian, Lin; Brichta, Lars; Greengard, Paul; Krainc, Dimitri; Schumacker, Paul T.; Surmeier, D. James.

In: Nature Neuroscience, Vol. 23, No. 1, 01.01.2020, p. 15-20.

Research output: Contribution to journalArticle

Graves, SM, Xie, Z, Stout, KA, Zampese, E, Burbulla, LF, Shih, JC, Kondapalli, J, Patriarchi, T, Tian, L, Brichta, L, Greengard, P, Krainc, D, Schumacker, PT & Surmeier, DJ 2020, 'Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain', Nature Neuroscience, vol. 23, no. 1, pp. 15-20. https://doi.org/10.1038/s41593-019-0556-3
Graves, Steven M. ; Xie, Zhong ; Stout, Kristen A. ; Zampese, Enrico ; Burbulla, Lena F. ; Shih, Jean C. ; Kondapalli, Jyothisri ; Patriarchi, Tomasso ; Tian, Lin ; Brichta, Lars ; Greengard, Paul ; Krainc, Dimitri ; Schumacker, Paul T. ; Surmeier, D. James. / Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. In: Nature Neuroscience. 2020 ; Vol. 23, No. 1. pp. 15-20.
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