Abstract
A group of people with Parkinson's disease and a group of matched controls were tested on a task involving a switch between perceptual dimensions. Patients were tested both 'on' and 'off' their normal medication cycles. Stimuli appeared in pairs for each trial, with each stimulus consisting of a color and a shape. One dimension of color and one of shape were mapped to each of two response keys. A cue was presented concurrently with each stimulus to indicate whether to respond on the basis of color or shape, following procedures developed by Hayes et al. [Hayes, A.E., Davidson, M.C., Keele, S.W., & Rafal, R.D. (1998). Toward a functional analysis of the basal ganglia. Journal of Cognitive Neuroscience, 10, 178-198]. Replicating previous literature, abnormally large switch costs were observed in patients who were off their normal medication cycles. A novel finding was that patients in the 'on' state demonstrated a slight reversal of switch costs. Also novel, reaction time (RT) costs associated with switching between response keys, and interactions between response switching and task switching were influenced predominantly by on-off dopamine manipulations. It is concluded that abnormal task switching costs and response repetition effects likely reflect impairments of activation and inhibition, and both effects are dopamine-dependent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1990-1999 |
| Number of pages | 10 |
| Journal | Neuropsychologia |
| Volume | 43 |
| Issue number | 14 |
| DOIs | |
| State | Published - 2005 |
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Keywords
- Cognitive switching
- Dopamine
- Parkinson's disease
- Response repetition
ASJC Scopus subject areas
- Behavioral Neuroscience
- Neuropsychology and Physiological Psychology
Cite this
Dopamine dependency of cognitive switching and response repetition effects in Parkinson's patients. / Shook, Sheryl K.; Franz, Elizabeth A.; Higginson, Christopher I.; Wheelock, Vicki L; Sigvardt, Karen A.
In: Neuropsychologia, Vol. 43, No. 14, 2005, p. 1990-1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine dependency of cognitive switching and response repetition effects in Parkinson's patients
AU - Shook, Sheryl K.
AU - Franz, Elizabeth A.
AU - Higginson, Christopher I.
AU - Wheelock, Vicki L
AU - Sigvardt, Karen A.
PY - 2005
Y1 - 2005
N2 - A group of people with Parkinson's disease and a group of matched controls were tested on a task involving a switch between perceptual dimensions. Patients were tested both 'on' and 'off' their normal medication cycles. Stimuli appeared in pairs for each trial, with each stimulus consisting of a color and a shape. One dimension of color and one of shape were mapped to each of two response keys. A cue was presented concurrently with each stimulus to indicate whether to respond on the basis of color or shape, following procedures developed by Hayes et al. [Hayes, A.E., Davidson, M.C., Keele, S.W., & Rafal, R.D. (1998). Toward a functional analysis of the basal ganglia. Journal of Cognitive Neuroscience, 10, 178-198]. Replicating previous literature, abnormally large switch costs were observed in patients who were off their normal medication cycles. A novel finding was that patients in the 'on' state demonstrated a slight reversal of switch costs. Also novel, reaction time (RT) costs associated with switching between response keys, and interactions between response switching and task switching were influenced predominantly by on-off dopamine manipulations. It is concluded that abnormal task switching costs and response repetition effects likely reflect impairments of activation and inhibition, and both effects are dopamine-dependent.
AB - A group of people with Parkinson's disease and a group of matched controls were tested on a task involving a switch between perceptual dimensions. Patients were tested both 'on' and 'off' their normal medication cycles. Stimuli appeared in pairs for each trial, with each stimulus consisting of a color and a shape. One dimension of color and one of shape were mapped to each of two response keys. A cue was presented concurrently with each stimulus to indicate whether to respond on the basis of color or shape, following procedures developed by Hayes et al. [Hayes, A.E., Davidson, M.C., Keele, S.W., & Rafal, R.D. (1998). Toward a functional analysis of the basal ganglia. Journal of Cognitive Neuroscience, 10, 178-198]. Replicating previous literature, abnormally large switch costs were observed in patients who were off their normal medication cycles. A novel finding was that patients in the 'on' state demonstrated a slight reversal of switch costs. Also novel, reaction time (RT) costs associated with switching between response keys, and interactions between response switching and task switching were influenced predominantly by on-off dopamine manipulations. It is concluded that abnormal task switching costs and response repetition effects likely reflect impairments of activation and inhibition, and both effects are dopamine-dependent.
KW - Cognitive switching
KW - Dopamine
KW - Parkinson's disease
KW - Response repetition
UR - http://www.scopus.com/inward/record.url?scp=26944466774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26944466774&partnerID=8YFLogxK
U2 - 10.1016/j.neuropsychologia.2005.03.024
DO - 10.1016/j.neuropsychologia.2005.03.024
M3 - Article
C2 - 16243049
AN - SCOPUS:26944466774
VL - 43
SP - 1990
EP - 1999
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
IS - 14
ER -