Dopamine and the mechanisms of cognition: Part II. D-amphetamine effects in human subjects performing a selective attention task

David Servan-Schreiber, Cameron S Carter, Randy M. Bruno, Jonathan D. Cohen

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: A neural network computer model described in a companion paper predicted the effects of increased dopamine transmission on selective attention under two different hypotheses. Methods: To evaluate these predictions we conducted an empirical study in human subjects of D- amphetamine effects on performance of the Eriksen response competition task. Ten healthy volunteers were tested before and after placebo or D-amphetamine in a double-blind crossover design. Results: D-amphetamine induced a speeding of reaction time overall and an improvement of accuracy at fast reaction times but only in the task condition requiring selective attention. Conclusions: This pattern of results conforms to the prediction of the model under the hypothesis that D-amphetamine primarily affects dopamine transmission in cognitive rather than motor networks. This suggests that the principles embodied in parallel distributed processing models of task performance may be sufficient to predict and explain specific behavioral effects of some drug actions in the central nervous system.

Original languageEnglish (US)
Pages (from-to)723-729
Number of pages7
JournalBiological Psychiatry
Volume43
Issue number10
DOIs
StatePublished - May 15 1998
Externally publishedYes

Fingerprint

Amphetamine
Cognition
Dopamine
Neural Networks (Computer)
Reaction Time
Task Performance and Analysis
Computer Simulation
Cross-Over Studies
Healthy Volunteers
Central Nervous System
Placebos
Pharmaceutical Preparations

Keywords

  • Computer models
  • D-amphetamine
  • Dopamine
  • Eriksen task
  • Gain
  • Information processing
  • Neural networks
  • Parallel distributed processing
  • Selective attention

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Dopamine and the mechanisms of cognition : Part II. D-amphetamine effects in human subjects performing a selective attention task. / Servan-Schreiber, David; Carter, Cameron S; Bruno, Randy M.; Cohen, Jonathan D.

In: Biological Psychiatry, Vol. 43, No. 10, 15.05.1998, p. 723-729.

Research output: Contribution to journalArticle

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