Abstract
Background: A neural network computer model described in a companion paper predicted the effects of increased dopamine transmission on selective attention under two different hypotheses. Methods: To evaluate these predictions we conducted an empirical study in human subjects of D- amphetamine effects on performance of the Eriksen response competition task. Ten healthy volunteers were tested before and after placebo or D-amphetamine in a double-blind crossover design. Results: D-amphetamine induced a speeding of reaction time overall and an improvement of accuracy at fast reaction times but only in the task condition requiring selective attention. Conclusions: This pattern of results conforms to the prediction of the model under the hypothesis that D-amphetamine primarily affects dopamine transmission in cognitive rather than motor networks. This suggests that the principles embodied in parallel distributed processing models of task performance may be sufficient to predict and explain specific behavioral effects of some drug actions in the central nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 723-729 |
| Number of pages | 7 |
| Journal | Biological Psychiatry |
| Volume | 43 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 15 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Computer models
- D-amphetamine
- Dopamine
- Eriksen task
- Gain
- Information processing
- Neural networks
- Parallel distributed processing
- Selective attention
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Dopamine and the mechanisms of cognition : Part II. D-amphetamine effects in human subjects performing a selective attention task. / Servan-Schreiber, David; Carter, Cameron S; Bruno, Randy M.; Cohen, Jonathan D.
In: Biological Psychiatry, Vol. 43, No. 10, 15.05.1998, p. 723-729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine and the mechanisms of cognition
T2 - Part II. D-amphetamine effects in human subjects performing a selective attention task
AU - Servan-Schreiber, David
AU - Carter, Cameron S
AU - Bruno, Randy M.
AU - Cohen, Jonathan D.
PY - 1998/5/15
Y1 - 1998/5/15
N2 - Background: A neural network computer model described in a companion paper predicted the effects of increased dopamine transmission on selective attention under two different hypotheses. Methods: To evaluate these predictions we conducted an empirical study in human subjects of D- amphetamine effects on performance of the Eriksen response competition task. Ten healthy volunteers were tested before and after placebo or D-amphetamine in a double-blind crossover design. Results: D-amphetamine induced a speeding of reaction time overall and an improvement of accuracy at fast reaction times but only in the task condition requiring selective attention. Conclusions: This pattern of results conforms to the prediction of the model under the hypothesis that D-amphetamine primarily affects dopamine transmission in cognitive rather than motor networks. This suggests that the principles embodied in parallel distributed processing models of task performance may be sufficient to predict and explain specific behavioral effects of some drug actions in the central nervous system.
AB - Background: A neural network computer model described in a companion paper predicted the effects of increased dopamine transmission on selective attention under two different hypotheses. Methods: To evaluate these predictions we conducted an empirical study in human subjects of D- amphetamine effects on performance of the Eriksen response competition task. Ten healthy volunteers were tested before and after placebo or D-amphetamine in a double-blind crossover design. Results: D-amphetamine induced a speeding of reaction time overall and an improvement of accuracy at fast reaction times but only in the task condition requiring selective attention. Conclusions: This pattern of results conforms to the prediction of the model under the hypothesis that D-amphetamine primarily affects dopamine transmission in cognitive rather than motor networks. This suggests that the principles embodied in parallel distributed processing models of task performance may be sufficient to predict and explain specific behavioral effects of some drug actions in the central nervous system.
KW - Computer models
KW - D-amphetamine
KW - Dopamine
KW - Eriksen task
KW - Gain
KW - Information processing
KW - Neural networks
KW - Parallel distributed processing
KW - Selective attention
UR - http://www.scopus.com/inward/record.url?scp=0032523960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032523960&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(97)00449-6
DO - 10.1016/S0006-3223(97)00449-6
M3 - Article
C2 - 9606525
AN - SCOPUS:0032523960
VL - 43
SP - 723
EP - 729
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 10
ER -