Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome

Joel P. Bish, Renee Chiodo, Victoria Mattei, Tony J Simon

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


One of the defining cognitive characteristics of the chromosome 22q deletion syndrome (DS22q11.2) is visuospatial processing impairments. The purpose of this study was to investigate and extend the specific attentional profile of children with this disorder using both an object-based attention task and an inhibition of return task. A group of children with the disorder was compared in these tasks with a group of age-matched typically developing children. The children with DS22q11.2 demonstrated impaired spatially based orienting which is consistent with previous findings in this group. Strikingly, the children with DS22q11.2 also demonstrated an improved ability to use object-based cues, relative to the typically developing group. Finally, the children with DS22q11.2 demonstrated an intact inhibition of return system, however, it appears to be delayed developmentally.

Original languageEnglish (US)
Pages (from-to)265-273
Number of pages9
JournalBrain and Cognition
Issue number3
StatePublished - Aug 2007


  • 22q11.2
  • Inhibition of return
  • Object attention
  • Spatial attention

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology


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