Abstract
Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 386-394 |
| Number of pages | 9 |
| Journal | Nature Genetics |
| Volume | 9 |
| Issue number | 4 |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. / LaSalle, Janine M; Lalande, M.
In: Nature Genetics, Vol. 9, No. 4, 1995, p. 386-394.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution
AU - LaSalle, Janine M
AU - Lalande, M.
PY - 1995
Y1 - 1995
N2 - Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.
AB - Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.
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M3 - Article
VL - 9
SP - 386
EP - 394
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -