Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution

Janine M LaSalle, M. Lalande

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.

Original languageEnglish (US)
Pages (from-to)386-394
Number of pages9
JournalNature Genetics
Volume9
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Multigene Family
Alleles
S Phase
Chromosomes, Human, Pair 15
Chromosomes
Mothers
Uniparental Disomy
Genomic Imprinting
Aminobutyrates
Chromatin
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. / LaSalle, Janine M; Lalande, M.

In: Nature Genetics, Vol. 9, No. 4, 1995, p. 386-394.

Research output: Contribution to journalArticle

@article{0cc77aa535334d128330658188e77036,
title = "Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution",
abstract = "Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.",
author = "LaSalle, {Janine M} and M. Lalande",
year = "1995",
language = "English (US)",
volume = "9",
pages = "386--394",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution

AU - LaSalle, Janine M

AU - Lalande, M.

PY - 1995

Y1 - 1995

N2 - Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.

AB - Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.

UR - http://www.scopus.com/inward/record.url?scp=0028937174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028937174&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 386

EP - 394

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -