Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution

Janine M LaSalle, M. Lalande

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Imprinting marks the parental origin of chromosomes, resulting in allele- specific changes in chromatin organization, transcription and replication. We report a 50-60 kb domain of allele-specific replication between the γ- aminobutyric acid receptor subunit β3 (GABRB3) and α5 (GABRA5) genes. Replication of this domain occurs in early S phase on the maternal chromosome 15 but is delayed until the end of S phase on the paternal homologue. In contrast, the genomic regions flanking this domain exhibit paternal earlier replication in mid to late S phase. Uniparental disomy or hemizygous deletion of chromosome 15 results in altered allele-specific replication kinetics compared with normals, suggesting that allele-specific replication within the GABRB3/A5 region may be regulated by reciprocal imprints on the maternal and paternal chromosomes.

Original languageEnglish (US)
Pages (from-to)386-394
Number of pages9
JournalNature Genetics
Volume9
Issue number4
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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