DoI detector design and characterization for open-field mouse brain PET

Andre Z. Kyme, Martin S. Judenhofer, Steven R. Meikle, Simon R Cherry

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Open-field' PET imaging of freely moving rodents is a powerful paradigm because it enables the correlation of functional and behavioral outputs in response to environmental or pharmacologic stimuli. Use of motion compensation techniques provides a feasible framework for imaging a moving animal. However, to overcome the geometric and performance limitations encountered in adapting motion compensation techniques to existing scanners, we are developing a purpose-built PET imaging system for freely moving mice. Two important innovations of this scanner are panel detectors with thick (20 mm) scintillators arranged in a tightly packed box geometry to provide high sensitivity (~15%) and a motion-controlled sliding gantry moving in synchrony with the animal. Here we describe the design and characterization of the depth-of-interaction (Dol) detector module forming the basis of a prototype system. The detector comprises a 23x23 LYSO crystal array, 0.85 mm pitch, 20 mm length, read out at both ends using 6x6 arrays of through-silicon-via (TSV) silicon photomultipliers. The crystal, photodiode arrays and light guide exactly matched to minimize gaps between neighboring modules. A cross-wire readout with resistive weighting was used to provide 4 position and one timing output per array, i.e. 10 outputs/module. Average energy resolution was 17.6 ± 5.3%. Average Dol resolution near the center of the crystal (10 mm) was 2.8 ± 0.35 mm and 3.5 ± 1.0 mm near the edges. This almost meets our target Dol of <3 mm to provide near-isotropic spatial resolution of ∼1 mm throughout the FoV. The timing resolution was 1.4 ± 0.14 ns. Manufacturing flaws in our scintillator array, particularly the integrity of the reflector material and its bonding to the individual crystals, likely compromised light collection and uniformity in our characterization of Dol and energy resolution. Therefore, although the results are promising, we expect improved performance in these parameters with a new crystal array.

Original languageEnglish (US)
Title of host publication2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Volume2017-January
ISBN (Electronic)9781509016426
DOIs
StatePublished - Oct 16 2017
Event2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - Strasbourg, France
Duration: Oct 29 2016Nov 6 2016

Other

Other2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Country/TerritoryFrance
CityStrasbourg
Period10/29/1611/6/16

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Instrumentation
  • Nuclear and High Energy Physics
  • Electronic, Optical and Magnetic Materials

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