Abstract
Inhibition of the release of substance P in trigeminal slices by opiates (Jessel & Iversen, 1977) provides support for the hypothesis that opiates produce presynaptic inhibition. The authors have used a modification of the excitability testing method (see Schmidt, 1971) to measure possible long-term opiate-produced polarization changes at cutaneous myelinated (A) and unmyelinated (C) afferent fiber terminals in the spinal cord. The results thus show that morphine might act at intraspinal terminals of cutaneous C fibers. However, the excitability changes observed do not reflect primary afferent depolarization as the underlying mechanism. Alternative possibilities for a presynaptic inhibitory action of morphine are discussed.
| Original language | English (US) |
|---|---|
| Journal | Journal of Physiology |
| Volume | VOL. 284 |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
Cite this
Does morphine produce presynaptic inhibition in the spinal cord? / Carstens, Earl; Tulloch, I.; Zieglgaensberger, W.; Zimmermann, M.
In: Journal of Physiology, Vol. VOL. 284, 1978.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does morphine produce presynaptic inhibition in the spinal cord?
AU - Carstens, Earl
AU - Tulloch, I.
AU - Zieglgaensberger, W.
AU - Zimmermann, M.
PY - 1978
Y1 - 1978
N2 - Inhibition of the release of substance P in trigeminal slices by opiates (Jessel & Iversen, 1977) provides support for the hypothesis that opiates produce presynaptic inhibition. The authors have used a modification of the excitability testing method (see Schmidt, 1971) to measure possible long-term opiate-produced polarization changes at cutaneous myelinated (A) and unmyelinated (C) afferent fiber terminals in the spinal cord. The results thus show that morphine might act at intraspinal terminals of cutaneous C fibers. However, the excitability changes observed do not reflect primary afferent depolarization as the underlying mechanism. Alternative possibilities for a presynaptic inhibitory action of morphine are discussed.
AB - Inhibition of the release of substance P in trigeminal slices by opiates (Jessel & Iversen, 1977) provides support for the hypothesis that opiates produce presynaptic inhibition. The authors have used a modification of the excitability testing method (see Schmidt, 1971) to measure possible long-term opiate-produced polarization changes at cutaneous myelinated (A) and unmyelinated (C) afferent fiber terminals in the spinal cord. The results thus show that morphine might act at intraspinal terminals of cutaneous C fibers. However, the excitability changes observed do not reflect primary afferent depolarization as the underlying mechanism. Alternative possibilities for a presynaptic inhibitory action of morphine are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018039787&partnerID=8YFLogxK
M3 - Article
C2 - 731483
AN - SCOPUS:0018039787
VL - VOL. 284
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
ER -