Does morphine produce presynaptic inhibition in the spinal cord?

Earl Carstens, I. Tulloch, W. Zieglgaensberger, M. Zimmermann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inhibition of the release of substance P in trigeminal slices by opiates (Jessel & Iversen, 1977) provides support for the hypothesis that opiates produce presynaptic inhibition. The authors have used a modification of the excitability testing method (see Schmidt, 1971) to measure possible long-term opiate-produced polarization changes at cutaneous myelinated (A) and unmyelinated (C) afferent fiber terminals in the spinal cord. The results thus show that morphine might act at intraspinal terminals of cutaneous C fibers. However, the excitability changes observed do not reflect primary afferent depolarization as the underlying mechanism. Alternative possibilities for a presynaptic inhibitory action of morphine are discussed.

Original languageEnglish (US)
JournalJournal of Physiology
VolumeVOL. 284
StatePublished - 1978
Externally publishedYes

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Opiate Alkaloids
Morphine
Spinal Cord
Unmyelinated Nerve Fibers
Skin
Substance P

ASJC Scopus subject areas

  • Physiology

Cite this

Carstens, E., Tulloch, I., Zieglgaensberger, W., & Zimmermann, M. (1978). Does morphine produce presynaptic inhibition in the spinal cord? Journal of Physiology, VOL. 284.

Does morphine produce presynaptic inhibition in the spinal cord? / Carstens, Earl; Tulloch, I.; Zieglgaensberger, W.; Zimmermann, M.

In: Journal of Physiology, Vol. VOL. 284, 1978.

Research output: Contribution to journalArticle

Carstens, E, Tulloch, I, Zieglgaensberger, W & Zimmermann, M 1978, 'Does morphine produce presynaptic inhibition in the spinal cord?', Journal of Physiology, vol. VOL. 284.
Carstens E, Tulloch I, Zieglgaensberger W, Zimmermann M. Does morphine produce presynaptic inhibition in the spinal cord? Journal of Physiology. 1978;VOL. 284.
Carstens, Earl ; Tulloch, I. ; Zieglgaensberger, W. ; Zimmermann, M. / Does morphine produce presynaptic inhibition in the spinal cord?. In: Journal of Physiology. 1978 ; Vol. VOL. 284.
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