Does morphine produce presynaptic inhibition in the spinal cord?

Earl Carstens, I. Tulloch, W. Zieglgaensberger, M. Zimmermann

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Inhibition of the release of substance P in trigeminal slices by opiates (Jessel & Iversen, 1977) provides support for the hypothesis that opiates produce presynaptic inhibition. The authors have used a modification of the excitability testing method (see Schmidt, 1971) to measure possible long-term opiate-produced polarization changes at cutaneous myelinated (A) and unmyelinated (C) afferent fiber terminals in the spinal cord. The results thus show that morphine might act at intraspinal terminals of cutaneous C fibers. However, the excitability changes observed do not reflect primary afferent depolarization as the underlying mechanism. Alternative possibilities for a presynaptic inhibitory action of morphine are discussed.

Original languageEnglish (US)
JournalJournal of Physiology
VolumeVOL. 284
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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  • Cite this

    Carstens, E., Tulloch, I., Zieglgaensberger, W., & Zimmermann, M. (1978). Does morphine produce presynaptic inhibition in the spinal cord? Journal of Physiology, VOL. 284.