Does inflammation have a role in the pathogenesis of venous ulcers: A critical review of the evidence

Yen Chen Liu, David J. Margolis, Roslyn Rivkah Isseroff

Research output: Contribution to journalArticle

30 Scopus citations


Chronic venous disease, a disorder involving venous return from the legs, is a growing epidemic in the developed world. Numerous studies have been conducted in the past two decades in an attempt to elucidate its underlying pathophysiology. Many theories have been proposed to address the profound inflammatory dysregulation, with the majority focusing on fibrin trap, inflammatory trap, cytokines, growth factors, and matrix metalloproteinases. Although many of these theories have obtained great momentum, much of the data are contradictory. Moreover, many treatments built on these theories have claimed overwhelming success despite insufficient evidence. At the same time, there are few reviews that critically analyze and evaluate these data. Therefore, in this paper, we will provide summaries of the background data and evolution of these theories and examine their supporting evidence.

Original languageEnglish (US)
Pages (from-to)818-827
Number of pages10
JournalJournal of Investigative Dermatology
Issue number4
StatePublished - Apr 2011


ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

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