Abstract
Chronic venous disease, a disorder involving venous return from the legs, is a growing epidemic in the developed world. Numerous studies have been conducted in the past two decades in an attempt to elucidate its underlying pathophysiology. Many theories have been proposed to address the profound inflammatory dysregulation, with the majority focusing on fibrin trap, inflammatory trap, cytokines, growth factors, and matrix metalloproteinases. Although many of these theories have obtained great momentum, much of the data are contradictory. Moreover, many treatments built on these theories have claimed overwhelming success despite insufficient evidence. At the same time, there are few reviews that critically analyze and evaluate these data. Therefore, in this paper, we will provide summaries of the background data and evolution of these theories and examine their supporting evidence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 818-827 |
| Number of pages | 10 |
| Journal | Journal of Investigative Dermatology |
| Volume | 131 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2011 |
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ASJC Scopus subject areas
- Dermatology
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Does inflammation have a role in the pathogenesis of venous ulcers : A critical review of the evidence. / Liu, Yen Chen; Margolis, David J.; Isseroff, Roslyn Rivkah.
In: Journal of Investigative Dermatology, Vol. 131, No. 4, 04.2011, p. 818-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does inflammation have a role in the pathogenesis of venous ulcers
T2 - A critical review of the evidence
AU - Liu, Yen Chen
AU - Margolis, David J.
AU - Isseroff, Roslyn Rivkah
PY - 2011/4
Y1 - 2011/4
N2 - Chronic venous disease, a disorder involving venous return from the legs, is a growing epidemic in the developed world. Numerous studies have been conducted in the past two decades in an attempt to elucidate its underlying pathophysiology. Many theories have been proposed to address the profound inflammatory dysregulation, with the majority focusing on fibrin trap, inflammatory trap, cytokines, growth factors, and matrix metalloproteinases. Although many of these theories have obtained great momentum, much of the data are contradictory. Moreover, many treatments built on these theories have claimed overwhelming success despite insufficient evidence. At the same time, there are few reviews that critically analyze and evaluate these data. Therefore, in this paper, we will provide summaries of the background data and evolution of these theories and examine their supporting evidence.
AB - Chronic venous disease, a disorder involving venous return from the legs, is a growing epidemic in the developed world. Numerous studies have been conducted in the past two decades in an attempt to elucidate its underlying pathophysiology. Many theories have been proposed to address the profound inflammatory dysregulation, with the majority focusing on fibrin trap, inflammatory trap, cytokines, growth factors, and matrix metalloproteinases. Although many of these theories have obtained great momentum, much of the data are contradictory. Moreover, many treatments built on these theories have claimed overwhelming success despite insufficient evidence. At the same time, there are few reviews that critically analyze and evaluate these data. Therefore, in this paper, we will provide summaries of the background data and evolution of these theories and examine their supporting evidence.
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U2 - 10.1038/jid.2010.428
DO - 10.1038/jid.2010.428
M3 - Article
C2 - 21307876
AN - SCOPUS:79952754786
VL - 131
SP - 818
EP - 827
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 4
ER -