Does exercise training lessen ischemia-induced dysfunction of resistance vessels in stunned myocardium?

J. D. Symons, S. V. Rendig, J. Benton, Charles L Stebbins, J. C. Longhurst

Research output: Contribution to journalArticlepeer-review

Abstract

We hypothesized that exercise training attenuates ischemia-induced endothelial dysfunction of coronary resistance vessels in acutely-stunned (Stun) myocardium. Rats were treadmill-trained (Ex+Stun, n=7) or cage-confined (Stun, n=11) for 10 weeks. Arterial and left ventricular pressure, and systolic wall thickening (Wth), then were measured in response to 3 cycles of ischemia (I; coronary occlusion, 10 min) and reperfusion (R; 10 min) to induce stunning. Age-matched rats served as sham-operated controls (Sham, n=12). After the third I/R (or sham) cycle, resistance vessels from the stunned myocardium were dissected and mounted in a myograph to evaluate endothelium-dependent (ACh) and independent (SNP) function, *p<0.05 vs Stun and Ex+Stun. Our results suggest that exercise training does not attenuate ischemia-induced endothelial dysfunction in this model of myocardial stunning. (Graph Presented).

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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