Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study

Jean Michel Chardigny, Frédéric Destaillats, Corinne Malpuech-Brugère, Julie Moulin, Dale E. Bauman, Adam L. Lock, Dave M. Barbano, Ronald P. Mensink, Jean Baptiste Bezelgues, Patrice Chaumont, Nicole Combe, Isabelle Cristiani, Florent Joffre, J. Bruce German, Fabiola Dionisi, Yves Boirie, Jean Louis Sébédio

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Background: The consumption of monounsaturated trans fatty acids (TFAs) increases the risk of cardiovascular disease (CVD). Putative differences between the effects of TFAs from industrially produced and natural sources on CVD risk markers were not previously investigated in healthy subjects. Objective: We aimed to compare the effects of TFAs from industrially produced and natural sources on HDL and LDL cholesterol, lipoprotein particle size and distribution, apolipoproteins, and other lipids in healthy subjects. Design: In a randomized, double-blind, controlled, crossover design, 46 healthy subjects (22 men and 24 women) consumed food items containing TFAs (11-12 g/d, representing ≈5% of daily energy) from the 2 sources. Results: Forty subjects (19 men and 21 women) completed the study. Compared with TFAs from industrially produced sources, TFAs from natural sources significantly (P = 0.012) increased HDL cholesterol in women but not in men. Significant (P = 0.001) increases in LDL-cholesterol concentrations were observed in women, but not in men, after the consumption of TFAs from natural sources. Apolipoprotein (apo)B and apoA1 concentrations confirmed the changes observed in LDL and HDL cholesterol. Analysis of lipoprotein subclass showed that only large HDL and LDL concentrations were modified by TFAs from natural sources but not by those from industrially produced sources. Conclusions: This study shows that TFAs from industrially produced and from natural sources have different effects on CVD risk factors in women. The HDL cholesterol-lowering property of TFAs seems to be specific to industrial sources. However, it is difficult in the present study to draw a conclusion about the effect of TFAs from either source on absolute CVD risk in these normolipidemic subjects. The mechanism underlying the observed sex- and isomer-specific effects warrants further investigation.

Original languageEnglish (US)
Pages (from-to)558-566
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number3
StatePublished - Mar 1 2008

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Trans Fatty Acids
trans fatty acids
cardiovascular diseases
Healthy Volunteers
Cardiovascular Diseases
risk factors
high density lipoprotein cholesterol
HDL Cholesterol
low density lipoprotein cholesterol
LDL Cholesterol
lipoproteins
Monounsaturated Fatty Acids
apolipoprotein B
apolipoproteins
cholesteremic effect
Apolipoproteins
Apolipoproteins B
monounsaturated fatty acids
LDL Lipoproteins
Particle Size

Keywords

  • Cardiovascular disease risk factor
  • Cholesterol
  • Lipoprotein
  • Nutrition in public health
  • Trans fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. / Chardigny, Jean Michel; Destaillats, Frédéric; Malpuech-Brugère, Corinne; Moulin, Julie; Bauman, Dale E.; Lock, Adam L.; Barbano, Dave M.; Mensink, Ronald P.; Bezelgues, Jean Baptiste; Chaumont, Patrice; Combe, Nicole; Cristiani, Isabelle; Joffre, Florent; German, J. Bruce; Dionisi, Fabiola; Boirie, Yves; Sébédio, Jean Louis.

In: American Journal of Clinical Nutrition, Vol. 87, No. 3, 01.03.2008, p. 558-566.

Research output: Contribution to journalArticle

Chardigny, JM, Destaillats, F, Malpuech-Brugère, C, Moulin, J, Bauman, DE, Lock, AL, Barbano, DM, Mensink, RP, Bezelgues, JB, Chaumont, P, Combe, N, Cristiani, I, Joffre, F, German, JB, Dionisi, F, Boirie, Y & Sébédio, JL 2008, 'Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study', American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 558-566.
Chardigny, Jean Michel ; Destaillats, Frédéric ; Malpuech-Brugère, Corinne ; Moulin, Julie ; Bauman, Dale E. ; Lock, Adam L. ; Barbano, Dave M. ; Mensink, Ronald P. ; Bezelgues, Jean Baptiste ; Chaumont, Patrice ; Combe, Nicole ; Cristiani, Isabelle ; Joffre, Florent ; German, J. Bruce ; Dionisi, Fabiola ; Boirie, Yves ; Sébédio, Jean Louis. / Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. In: American Journal of Clinical Nutrition. 2008 ; Vol. 87, No. 3. pp. 558-566.
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AU - Malpuech-Brugère, Corinne

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AU - Bauman, Dale E.

AU - Lock, Adam L.

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N2 - Background: The consumption of monounsaturated trans fatty acids (TFAs) increases the risk of cardiovascular disease (CVD). Putative differences between the effects of TFAs from industrially produced and natural sources on CVD risk markers were not previously investigated in healthy subjects. Objective: We aimed to compare the effects of TFAs from industrially produced and natural sources on HDL and LDL cholesterol, lipoprotein particle size and distribution, apolipoproteins, and other lipids in healthy subjects. Design: In a randomized, double-blind, controlled, crossover design, 46 healthy subjects (22 men and 24 women) consumed food items containing TFAs (11-12 g/d, representing ≈5% of daily energy) from the 2 sources. Results: Forty subjects (19 men and 21 women) completed the study. Compared with TFAs from industrially produced sources, TFAs from natural sources significantly (P = 0.012) increased HDL cholesterol in women but not in men. Significant (P = 0.001) increases in LDL-cholesterol concentrations were observed in women, but not in men, after the consumption of TFAs from natural sources. Apolipoprotein (apo)B and apoA1 concentrations confirmed the changes observed in LDL and HDL cholesterol. Analysis of lipoprotein subclass showed that only large HDL and LDL concentrations were modified by TFAs from natural sources but not by those from industrially produced sources. Conclusions: This study shows that TFAs from industrially produced and from natural sources have different effects on CVD risk factors in women. The HDL cholesterol-lowering property of TFAs seems to be specific to industrial sources. However, it is difficult in the present study to draw a conclusion about the effect of TFAs from either source on absolute CVD risk in these normolipidemic subjects. The mechanism underlying the observed sex- and isomer-specific effects warrants further investigation.

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