Do kainate-lesioned hippocampi become epileptogenic?

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74 Scopus citations


Kainic acid lesions of hippocampal subfields CA3-CA4 produced dramatic synchronous afterdischarge activity in subfield CA1 when studied 2-4 weeks post-lesion in the in vitro slice preparation. This epileptiform discharge was correlated with a loss of intrinsic firing-induced afterhyperpolarizations and synaptic IPSPs. Two to 4 months post-lesion, intrinsic afterpotentials and synaptic inhibition appeared normal in most cells studied.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - Mar 11 1985
Externally publishedYes


  • epileptogenesis
  • hippocampus
  • kainate
  • lesions

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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