DNA Polymerase η (Eta)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA polymerase η is necessary for efficient repair/replication of ultraviolet (UV) radiation-induced DNA damage through translesion synthesis. Mutations in this gene result in xeroderma pigmentosum, variant type (XPV). Patients with this disease are highly susceptible to developing various types of skin cancers as a result of UV-induced DNA damage.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages375
Number of pages1
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013
Externally publishedYes

    Fingerprint

Keywords

  • DNA damage repair
  • Translesion synthesis
  • Ultraviolet radiation
  • Xeroderma pigmentosum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jen, K-Y. (2013). DNA Polymerase η (Eta). In Brenner's Encyclopedia of Genetics: Second Edition (pp. 375). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00426-5