DNA methylation alterations in Alzheimer's disease

Research output: Contribution to journalArticlepeer-review

Abstract

The observation that Alzheimer's disease (AD) patients with similar and even identical genetic backgrounds often present with heterogeneous pathologies has prompted the hypothesis that epigenetics may contribute to AD. While the study of epigenetics encompasses a variety of modifications including histone modifications and non-coding RNAs, much of the research on how epigenetics might impact AD pathology has been focused on DNA methylation. To this end, several studies have characterized DNA methylation alterations in various brain regions of individuals with AD, with conflicting results. This review examines the results of studies analyzing both global and gene-specific DNA methylation changes in AD and also assesses the results of studies analyzing DNA hydroxymethylation in patients with AD.

Original languageEnglish (US)
Article numberdvx008
JournalEnvironmental Epigenetics
Volume3
Issue number2
DOIs
StatePublished - May 1 2017

Keywords

  • Alzheimer's disease
  • dementia
  • DNA hydroxymethylation
  • DNA methylation
  • epigenetics

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'DNA methylation alterations in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this