DNA: Heritable Channelopathies and Selected Cardiomyopathies - Postmortem Assessment

K. A. Glatter, P. Sirish, M. Yamoah, Nipavan Chiamvimonvat

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sudden cardiac death, or death within 1. h of losing consciousness, remains an extremely important cause of death. It is frequently due to arrhythmias-like ventricular fibrillation. The use of molecular autopsies helps the forensic pathologist determine the cause of death with a normal autopsy. We will outline ion channelopathies (heritable causes of sudden unexplained death syndrome) that may be uncovered including long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, short QT syndrome, and early repolarization syndrome. Finally, we will discuss genetic disorders of the heart muscle that cause sudden death including hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy/dysplasia.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Forensic and Legal Medicine
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages343-350
Number of pages8
ISBN (Electronic)9780128000557
ISBN (Print)9780128000342
DOIs
StatePublished - Nov 4 2015

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy/dysplasia
  • Brugada syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
  • Early repolarization syndrome
  • Hypertrophic cardiomyopathy
  • Ion channelopathy
  • Long QT syndrome
  • Molecular autopsy
  • Short QT syndrome
  • Sudden cardiac death
  • Sudden unexplained death syndrome

ASJC Scopus subject areas

  • Social Sciences(all)

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