DNA-Binding Proteins

Kuang-Yu Jen, A. Travers

Research output: Chapter in Book/Report/Conference proceedingChapter


DNA-binding proteins consist of a large class of proteins which can physically interact with DNA. These proteins serve a variety of functions including chromosomal DNA organization/compaction (e.g., histones); initiation and regulation of transcription, DNA replication, and/or DNA recombination (e.g., transcription factors, polymerases); and DNA modification (e.g., endonucleases, demethylases). Some DNA-binding proteins exhibit DNA sequence-specific interactions, while others lack or have minimal sequence recognition capability. Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013
Externally publishedYes


  • DNA binding
  • Domain
  • Motif
  • Sequence specificity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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