DNA-Binding Proteins

Kuang-Yu Jen, A. Travers

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA-binding proteins consist of a large class of proteins which can physically interact with DNA. These proteins serve a variety of functions including chromosomal DNA organization/compaction (e.g., histones); initiation and regulation of transcription, DNA replication, and/or DNA recombination (e.g., transcription factors, polymerases); and DNA modification (e.g., endonucleases, demethylases). Some DNA-binding proteins exhibit DNA sequence-specific interactions, while others lack or have minimal sequence recognition capability. Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages345-347
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013
Externally publishedYes

Fingerprint

DNA-binding proteins
DNA-Binding Proteins
DNA
proteins
DNA-binding domains
Proteins
DNA replication
histones
Endonucleases
DNA Replication
DNA sequences
Histones
transcription factors
transcription (genetics)
Genetic Recombination
Transcription
Transcription Factors
nucleotide sequences
Compaction

Keywords

  • DNA binding
  • Domain
  • Motif
  • Sequence specificity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jen, K-Y., & Travers, A. (2013). DNA-Binding Proteins. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 345-347). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00439-3

DNA-Binding Proteins. / Jen, Kuang-Yu; Travers, A.

Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 345-347.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jen, K-Y & Travers, A 2013, DNA-Binding Proteins. in Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., pp. 345-347. https://doi.org/10.1016/B978-0-12-374984-0.00439-3
Jen K-Y, Travers A. DNA-Binding Proteins. In Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc. 2013. p. 345-347 https://doi.org/10.1016/B978-0-12-374984-0.00439-3
Jen, Kuang-Yu ; Travers, A. / DNA-Binding Proteins. Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. pp. 345-347
@inbook{f851713749d54a88a74216caf1fa79fb,
title = "DNA-Binding Proteins",
abstract = "DNA-binding proteins consist of a large class of proteins which can physically interact with DNA. These proteins serve a variety of functions including chromosomal DNA organization/compaction (e.g., histones); initiation and regulation of transcription, DNA replication, and/or DNA recombination (e.g., transcription factors, polymerases); and DNA modification (e.g., endonucleases, demethylases). Some DNA-binding proteins exhibit DNA sequence-specific interactions, while others lack or have minimal sequence recognition capability. Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.",
keywords = "DNA binding, Domain, Motif, Sequence specificity",
author = "Kuang-Yu Jen and A. Travers",
year = "2013",
month = "2",
day = "27",
doi = "10.1016/B978-0-12-374984-0.00439-3",
language = "English (US)",
isbn = "9780123749840",
pages = "345--347",
booktitle = "Brenner's Encyclopedia of Genetics",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - DNA-Binding Proteins

AU - Jen, Kuang-Yu

AU - Travers, A.

PY - 2013/2/27

Y1 - 2013/2/27

N2 - DNA-binding proteins consist of a large class of proteins which can physically interact with DNA. These proteins serve a variety of functions including chromosomal DNA organization/compaction (e.g., histones); initiation and regulation of transcription, DNA replication, and/or DNA recombination (e.g., transcription factors, polymerases); and DNA modification (e.g., endonucleases, demethylases). Some DNA-binding proteins exhibit DNA sequence-specific interactions, while others lack or have minimal sequence recognition capability. Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.

AB - DNA-binding proteins consist of a large class of proteins which can physically interact with DNA. These proteins serve a variety of functions including chromosomal DNA organization/compaction (e.g., histones); initiation and regulation of transcription, DNA replication, and/or DNA recombination (e.g., transcription factors, polymerases); and DNA modification (e.g., endonucleases, demethylases). Some DNA-binding proteins exhibit DNA sequence-specific interactions, while others lack or have minimal sequence recognition capability. Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.

KW - DNA binding

KW - Domain

KW - Motif

KW - Sequence specificity

UR - http://www.scopus.com/inward/record.url?scp=85043278691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043278691&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374984-0.00439-3

DO - 10.1016/B978-0-12-374984-0.00439-3

M3 - Chapter

AN - SCOPUS:85043278691

SN - 9780123749840

SP - 345

EP - 347

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -