Abstract
The discovery of a new variation on the Davis-Beirut reaction is described in which an atypical heterocyclic framework (the anthranil or benzo[c]isoxazole framework) is formed as the result of diversion of a key reactive intermediate away from its expected reactivity - a potentially general approach to reaction design and development. Experimental and computational support for the proposed mechanism and origins of altered reactivity are described.
Original language | English (US) |
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Pages (from-to) | 10875-10882 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 82 |
Issue number | 20 |
DOIs | |
State | Published - Oct 20 2017 |
ASJC Scopus subject areas
- Organic Chemistry