TY - JOUR
T1 - Diversity of bat astroviruses in Lao PDR and Cambodia
AU - Lacroix, Audrey
AU - Duong, Veasna
AU - Hul, Vibol
AU - San, Sorn
AU - Davun, Holl
AU - Omaliss, Keo
AU - Chea, Sokha
AU - Hassanin, Alexandre
AU - Theppangna, Watthana
AU - Silithammavong, Soubanh
AU - Khammavong, Kongsy
AU - Singhalath, Sinpakone
AU - Afelt, Aneta
AU - Greatorex, Zoe
AU - Fine, Amanda E.
AU - Goldstein, Tracey
AU - Olson, Sarah
AU - Joly, Damien O.
AU - Keatts, Lucy
AU - Dussart, Philippe
AU - Frutos, Roger
AU - Buchy, Philippe
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Astroviruses are known to infect humans and a wide range of animal species, and can cause gastroenteritis in their hosts. Recent studies have reported astroviruses in bats in Europe and in several locations in China. We sampled 1876 bats from 17 genera at 45 sites from 14 and 13 provinces in Cambodia and Lao PDR respectively, and tested them for astroviruses. Our study revealed a high diversity of astroviruses among various Yangochiroptera and Yinpterochiroptera bats. Evidence for varying degrees of host restriction for astroviruses in bats was found. Furthermore, additional Pteropodid hosts were detected. The astroviruses formed distinct phylogenetic clusters within the genus Mamastrovirus, most closely related to other known bat astroviruses. The astrovirus sequences were found to be highly saturated indicating that phylogenetic relationships should be interpreted carefully. An astrovirus clustering in a group with other viruses from diverse hosts, including from ungulates and porcupines, was found in a Rousettus bat. These findings suggest that diverse astroviruses can be found in many species of mammals, including bats.
AB - Astroviruses are known to infect humans and a wide range of animal species, and can cause gastroenteritis in their hosts. Recent studies have reported astroviruses in bats in Europe and in several locations in China. We sampled 1876 bats from 17 genera at 45 sites from 14 and 13 provinces in Cambodia and Lao PDR respectively, and tested them for astroviruses. Our study revealed a high diversity of astroviruses among various Yangochiroptera and Yinpterochiroptera bats. Evidence for varying degrees of host restriction for astroviruses in bats was found. Furthermore, additional Pteropodid hosts were detected. The astroviruses formed distinct phylogenetic clusters within the genus Mamastrovirus, most closely related to other known bat astroviruses. The astrovirus sequences were found to be highly saturated indicating that phylogenetic relationships should be interpreted carefully. An astrovirus clustering in a group with other viruses from diverse hosts, including from ungulates and porcupines, was found in a Rousettus bat. These findings suggest that diverse astroviruses can be found in many species of mammals, including bats.
KW - Astroviruses
KW - Bats
KW - Cambodia
KW - Genetic diversity
KW - Lao PDR
UR - http://www.scopus.com/inward/record.url?scp=84995810537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995810537&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2016.11.013
DO - 10.1016/j.meegid.2016.11.013
M3 - Article
C2 - 27871796
AN - SCOPUS:84995810537
VL - 47
SP - 41
EP - 50
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
ER -