Diversity of bat astroviruses in Lao PDR and Cambodia

Audrey Lacroix, Veasna Duong, Vibol Hul, Sorn San, Holl Davun, Keo Omaliss, Sokha Chea, Alexandre Hassanin, Watthana Theppangna, Soubanh Silithammavong, Kongsy Khammavong, Sinpakone Singhalath, Aneta Afelt, Zoe Greatorex, Amanda E. Fine, Tracey Goldstein, Sarah Olson, Damien O. Joly, Lucy Keatts, Philippe DussartRoger Frutos, Philippe Buchy

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Astroviruses are known to infect humans and a wide range of animal species, and can cause gastroenteritis in their hosts. Recent studies have reported astroviruses in bats in Europe and in several locations in China. We sampled 1876 bats from 17 genera at 45 sites from 14 and 13 provinces in Cambodia and Lao PDR respectively, and tested them for astroviruses. Our study revealed a high diversity of astroviruses among various Yangochiroptera and Yinpterochiroptera bats. Evidence for varying degrees of host restriction for astroviruses in bats was found. Furthermore, additional Pteropodid hosts were detected. The astroviruses formed distinct phylogenetic clusters within the genus Mamastrovirus, most closely related to other known bat astroviruses. The astrovirus sequences were found to be highly saturated indicating that phylogenetic relationships should be interpreted carefully. An astrovirus clustering in a group with other viruses from diverse hosts, including from ungulates and porcupines, was found in a Rousettus bat. These findings suggest that diverse astroviruses can be found in many species of mammals, including bats.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalInfection, Genetics and Evolution
Volume47
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Astroviruses
  • Bats
  • Cambodia
  • Genetic diversity
  • Lao PDR

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lacroix, A., Duong, V., Hul, V., San, S., Davun, H., Omaliss, K., Chea, S., Hassanin, A., Theppangna, W., Silithammavong, S., Khammavong, K., Singhalath, S., Afelt, A., Greatorex, Z., Fine, A. E., Goldstein, T., Olson, S., Joly, D. O., Keatts, L., ... Buchy, P. (2017). Diversity of bat astroviruses in Lao PDR and Cambodia. Infection, Genetics and Evolution, 47, 41-50. https://doi.org/10.1016/j.meegid.2016.11.013