Diversity in the T cell response to Chlamydia-sum are better than one

Jasmine C. Labuda, Stephen J Mcsorley

Research output: Contribution to journalReview article

Abstract

Chlamydia trachomatis is responsible for an increasing number of sexually transmitted infections in the United States and is a common cause of serious pathology in the female reproductive tract (FRT). Given the impact and incidence of these infections, the production of an effective Chlamydia vaccine is a public health priority. Mouse models of Chlamydia infection have been utilized to develop a detailed and mechanistic understanding of protective immunity in the FRT. These studies reveal that MHC class-II restricted Chlamydia-specific CD4 T cells are critical for primary bacterial clearance and provide effective protection against secondary infection in the FRT. Despite the clear importance of IFN- γ produced by CD4 Th1 cells, there are also suggestions of wider functional heterogeneity in the CD4 T cell response to Chlamydia infection. Understanding the role of this diversity in the CD4 T helper cell response in the FRT should allow a more nuanced view of CD4 T cell biology in the context of Chlamydia infection and may be critical for vaccine development. Here, we summarize our current understanding of CD4 T helper subsets in the clearance of Chlamydia and discuss some areas where knowledge needs to be further extended by additional experimentation.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalImmunology Letters
Volume202
DOIs
StatePublished - Oct 1 2018

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Chlamydia
Chlamydia Infections
T-Lymphocytes
Vaccines
Health Priorities
Th1 Cells
Chlamydia trachomatis
Sexually Transmitted Diseases
Helper-Inducer T-Lymphocytes
Coinfection
Cell Biology
Immunity
Public Health
Pathology
Incidence
Infection

Keywords

  • CD4 T cells
  • Chlamydia
  • T helper subsets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Diversity in the T cell response to Chlamydia-sum are better than one. / Labuda, Jasmine C.; Mcsorley, Stephen J.

In: Immunology Letters, Vol. 202, 01.10.2018, p. 59-64.

Research output: Contribution to journalReview article

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