Diverse mechanisms of translation regulation and their role in cancer

Nancy Villa, Christopher S. Fraser

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Translation is a highly regulated multistep process that involves the recruitment of an mRNA to a ribosome and its translation by aminoacyl-tRNAs (aa-tRNA) into a polypeptide. Regulation can occur at any of the four stages of translation (initiation, elongation, termination, and ribosome recycling), and can be directed at the level of mRNA, translation factors, or the ribosome. In this chapter, we will review the diverse approaches the cell uses to regulate protein synthesis. Translation efficiency can be affected by mRNA sequence and structure elements, mRNA availability to the translation machinery, regulation of translation factor activity and availability, and regulation through changes in ribosome number and activity. We will also discuss how the translation machinery can be manipulated by cancer cells to promote tumorigenesis.

Original languageEnglish (US)
Title of host publicationTranslation and Its Regulation in Cancer Biology and Medicine
PublisherSpringer Netherlands
Pages39-71
Number of pages33
Volume9789401790789
ISBN (Print)9789401790789, 9401790779, 9789401790772
DOIs
StatePublished - Mar 1 2014

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Diverse mechanisms of translation regulation and their role in cancer'. Together they form a unique fingerprint.

  • Cite this

    Villa, N., & Fraser, C. S. (2014). Diverse mechanisms of translation regulation and their role in cancer. In Translation and Its Regulation in Cancer Biology and Medicine (Vol. 9789401790789, pp. 39-71). Springer Netherlands. https://doi.org/10.1007/978-94-017-9078-9_3