Diverse mechanisms of translation regulation and their role in cancer

Nancy Villa; Christopher S. Fraser

doi:10.1007/978-94-017-9078-9_3

Diverse mechanisms of translation regulation and their role in cancer

Nancy Villa, Christopher S. Fraser

Molecular and Cellular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Translation is a highly regulated multistep process that involves the recruitment of an mRNA to a ribosome and its translation by aminoacyl-tRNAs (aa-tRNA) into a polypeptide. Regulation can occur at any of the four stages of translation (initiation, elongation, termination, and ribosome recycling), and can be directed at the level of mRNA, translation factors, or the ribosome. In this chapter, we will review the diverse approaches the cell uses to regulate protein synthesis. Translation efficiency can be affected by mRNA sequence and structure elements, mRNA availability to the translation machinery, regulation of translation factor activity and availability, and regulation through changes in ribosome number and activity. We will also discuss how the translation machinery can be manipulated by cancer cells to promote tumorigenesis.

Original language	English (US)
Title of host publication	Translation and Its Regulation in Cancer Biology and Medicine
Publisher	Springer Netherlands
Pages	39-71
Number of pages	33
Volume	9789401790789
ISBN (Print)	9789401790789, 9401790779, 9789401790772
DOIs	https://doi.org/10.1007/978-94-017-9078-9_3
State	Published - Mar 1 2014

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-94-017-9078-9_3

Fingerprint Dive into the research topics of 'Diverse mechanisms of translation regulation and their role in cancer'. Together they form a unique fingerprint.

Cite this

Villa, N., & Fraser, C. S. (2014). Diverse mechanisms of translation regulation and their role in cancer. In Translation and Its Regulation in Cancer Biology and Medicine (Vol. 9789401790789, pp. 39-71). Springer Netherlands. https://doi.org/10.1007/978-94-017-9078-9_3

@inbook{d96324f7a2ec4e1eace4b7189004a88b,

title = "Diverse mechanisms of translation regulation and their role in cancer",

abstract = "Translation is a highly regulated multistep process that involves the recruitment of an mRNA to a ribosome and its translation by aminoacyl-tRNAs (aa-tRNA) into a polypeptide. Regulation can occur at any of the four stages of translation (initiation, elongation, termination, and ribosome recycling), and can be directed at the level of mRNA, translation factors, or the ribosome. In this chapter, we will review the diverse approaches the cell uses to regulate protein synthesis. Translation efficiency can be affected by mRNA sequence and structure elements, mRNA availability to the translation machinery, regulation of translation factor activity and availability, and regulation through changes in ribosome number and activity. We will also discuss how the translation machinery can be manipulated by cancer cells to promote tumorigenesis.",

author = "Nancy Villa and Fraser, {Christopher S.}",

year = "2014",

month = mar,

day = "1",

doi = "10.1007/978-94-017-9078-9_3",

language = "English (US)",

isbn = "9789401790789",

volume = "9789401790789",

pages = "39--71",

booktitle = "Translation and Its Regulation in Cancer Biology and Medicine",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Diverse mechanisms of translation regulation and their role in cancer

AU - Villa, Nancy

AU - Fraser, Christopher S.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Translation is a highly regulated multistep process that involves the recruitment of an mRNA to a ribosome and its translation by aminoacyl-tRNAs (aa-tRNA) into a polypeptide. Regulation can occur at any of the four stages of translation (initiation, elongation, termination, and ribosome recycling), and can be directed at the level of mRNA, translation factors, or the ribosome. In this chapter, we will review the diverse approaches the cell uses to regulate protein synthesis. Translation efficiency can be affected by mRNA sequence and structure elements, mRNA availability to the translation machinery, regulation of translation factor activity and availability, and regulation through changes in ribosome number and activity. We will also discuss how the translation machinery can be manipulated by cancer cells to promote tumorigenesis.

AB - Translation is a highly regulated multistep process that involves the recruitment of an mRNA to a ribosome and its translation by aminoacyl-tRNAs (aa-tRNA) into a polypeptide. Regulation can occur at any of the four stages of translation (initiation, elongation, termination, and ribosome recycling), and can be directed at the level of mRNA, translation factors, or the ribosome. In this chapter, we will review the diverse approaches the cell uses to regulate protein synthesis. Translation efficiency can be affected by mRNA sequence and structure elements, mRNA availability to the translation machinery, regulation of translation factor activity and availability, and regulation through changes in ribosome number and activity. We will also discuss how the translation machinery can be manipulated by cancer cells to promote tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=84930897578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930897578&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-9078-9_3

DO - 10.1007/978-94-017-9078-9_3

M3 - Chapter

AN - SCOPUS:84930897578

SN - 9789401790789

SN - 9401790779

SN - 9789401790772

VL - 9789401790789

SP - 39

EP - 71

BT - Translation and Its Regulation in Cancer Biology and Medicine

PB - Springer Netherlands

ER -