Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects. Methods: Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n=267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score for each marker category was calculated. Results: There was a contrasting pattern in systemic versus vascular inflammatory burden over age with an increase in systemic but a decrease in vascular markers in both ethnic groups. The results remained unchanged after adjustments for the covariates and covariance. When looking at individual markers to examine which markers are most contributing factors to the composite scores, CRP and SAA were significantly and positively associated with age, while PTX-3 and sVCAM were significantly and negatively associated with age in both ethnic groups. Conclusions: The composite z-score for systemic inflammation increased with age, while the composite z-score for vascular inflammation declined with age, irrespective of ethnicity. The findings illustrate a regulatory relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of physiological changes rather than reflecting a disease process.

Original languageEnglish (US)
Pages (from-to)509-515
Number of pages7
JournalAtherosclerosis
Volume239
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

African Americans
Blood Vessels
Inflammation
Serum Amyloid A Protein
Vascular Cell Adhesion Molecule-1
Ethnic Groups
C-Reactive Protein
Haptoglobins
Intercellular Adhesion Molecule-1
Fibrinogen
Glycoproteins
Healthy Volunteers
Cardiovascular Diseases
Acids
Population

Keywords

  • Composite score
  • Ethnicity
  • General population
  • Inflammatory biomarkers

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{2d85f45635fc43d0b8579686698ef46d,
title = "Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans",
abstract = "Objective: Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects. Methods: Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n=267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score for each marker category was calculated. Results: There was a contrasting pattern in systemic versus vascular inflammatory burden over age with an increase in systemic but a decrease in vascular markers in both ethnic groups. The results remained unchanged after adjustments for the covariates and covariance. When looking at individual markers to examine which markers are most contributing factors to the composite scores, CRP and SAA were significantly and positively associated with age, while PTX-3 and sVCAM were significantly and negatively associated with age in both ethnic groups. Conclusions: The composite z-score for systemic inflammation increased with age, while the composite z-score for vascular inflammation declined with age, irrespective of ethnicity. The findings illustrate a regulatory relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of physiological changes rather than reflecting a disease process.",
keywords = "Composite score, Ethnicity, General population, Inflammatory biomarkers",
author = "Enkhmaa Byambaa and Anuurad Erdembileg and Wei Zhang and Kyoungmi Kim and Lars Berglund",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.atherosclerosis.2015.02.023",
language = "English (US)",
volume = "239",
pages = "509--515",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans

AU - Byambaa, Enkhmaa

AU - Erdembileg, Anuurad

AU - Zhang, Wei

AU - Kim, Kyoungmi

AU - Berglund, Lars

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective: Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects. Methods: Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n=267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score for each marker category was calculated. Results: There was a contrasting pattern in systemic versus vascular inflammatory burden over age with an increase in systemic but a decrease in vascular markers in both ethnic groups. The results remained unchanged after adjustments for the covariates and covariance. When looking at individual markers to examine which markers are most contributing factors to the composite scores, CRP and SAA were significantly and positively associated with age, while PTX-3 and sVCAM were significantly and negatively associated with age in both ethnic groups. Conclusions: The composite z-score for systemic inflammation increased with age, while the composite z-score for vascular inflammation declined with age, irrespective of ethnicity. The findings illustrate a regulatory relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of physiological changes rather than reflecting a disease process.

AB - Objective: Age and inflammation are risk factors for cardiovascular disease but the impact of inflammation on cardiovascular risk across the lifespan is not understood. We investigated whether an inflammatory burden is modulated by age in healthy subjects. Methods: Caucasian and African-American families were recruited from the general population (age range: 6-74 years, n=267). Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM). To collectively assess systemic or vascular factors across the age spectrum, a composite z-score for each marker category was calculated. Results: There was a contrasting pattern in systemic versus vascular inflammatory burden over age with an increase in systemic but a decrease in vascular markers in both ethnic groups. The results remained unchanged after adjustments for the covariates and covariance. When looking at individual markers to examine which markers are most contributing factors to the composite scores, CRP and SAA were significantly and positively associated with age, while PTX-3 and sVCAM were significantly and negatively associated with age in both ethnic groups. Conclusions: The composite z-score for systemic inflammation increased with age, while the composite z-score for vascular inflammation declined with age, irrespective of ethnicity. The findings illustrate a regulatory relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of physiological changes rather than reflecting a disease process.

KW - Composite score

KW - Ethnicity

KW - General population

KW - Inflammatory biomarkers

UR - http://www.scopus.com/inward/record.url?scp=84923039209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923039209&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2015.02.023

DO - 10.1016/j.atherosclerosis.2015.02.023

M3 - Article

C2 - 25710295

AN - SCOPUS:84923039209

VL - 239

SP - 509

EP - 515

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -