Divergent behavior of mucosal memory T cells

O. H. Pham, Stephen J Mcsorley

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.

Original languageEnglish (US)
Pages (from-to)731-734
Number of pages4
JournalMucosal Immunology
Volume8
Issue number4
DOIs
StatePublished - Jul 25 2015

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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