Abstract
Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 731-734 |
| Number of pages | 4 |
| Journal | Mucosal Immunology |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 25 2015 |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Divergent behavior of mucosal memory T cells. / Pham, O. H.; Mcsorley, Stephen J.
In: Mucosal Immunology, Vol. 8, No. 4, 25.07.2015, p. 731-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Divergent behavior of mucosal memory T cells
AU - Pham, O. H.
AU - Mcsorley, Stephen J
PY - 2015/7/25
Y1 - 2015/7/25
N2 - Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.
AB - Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.
UR - http://www.scopus.com/inward/record.url?scp=84932649531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84932649531&partnerID=8YFLogxK
U2 - 10.1038/mi.2015.52
DO - 10.1038/mi.2015.52
M3 - Article
C2 - 26059005
AN - SCOPUS:84932649531
VL - 8
SP - 731
EP - 734
JO - Mucosal Immunology
JF - Mucosal Immunology
SN - 1933-0219
IS - 4
ER -