Divergent behavior of mucosal memory T cells

O. H. Pham, Stephen J Mcsorley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.

Original languageEnglish (US)
Pages (from-to)731-734
Number of pages4
JournalMucosal Immunology
Volume8
Issue number4
DOIs
StatePublished - Jul 25 2015

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T-Lymphocytes
Adaptive Immunity
T-Cell Antigen Receptor
Innate Immunity
Mucous Membrane
Inflammation
Population

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Divergent behavior of mucosal memory T cells. / Pham, O. H.; Mcsorley, Stephen J.

In: Mucosal Immunology, Vol. 8, No. 4, 25.07.2015, p. 731-734.

Research output: Contribution to journalArticle

Pham, O. H. ; Mcsorley, Stephen J. / Divergent behavior of mucosal memory T cells. In: Mucosal Immunology. 2015 ; Vol. 8, No. 4. pp. 731-734.
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