Distribution, pharmacokinetics, and metabolism of [14C]2,4-diamino-6-(2-furyl)-s-triazine in various developmental stages of the house fly

Isaac N Pessah, Robert E. Menzer, Alexej B. Borkovec

Research output: Contribution to journalArticle

Abstract

The distribution, elimination, and metabolism of [14C]AI3-22641 has been studied in various developmental stages of the house fly. Elimination of radiocarbon from imaginals followed firstorder kinetics with a t 1 2 of 6.3 hr. Eliminated were two very polar metabolites which appeared to have very similar chromatographic properties. [14C]AI3-22641 distributed into the eggs of treated females. Its concentration in the eggs appeared to follow its general elimination pattern from the imago body in situ. Once [14C]AI3-22641 was deposited into the eggs and they were oviposited, no elimination of the radiocarbon out of the eggs occurred until the time of hatching. During late embryonic development two polar metabolites of AI3-22641 appeared. They persisted in first instar larvae. These metabolites were probably the same as those eliminated by female imaginals. Extensive analysis of the major metabolite was undertaken using derivatization techniques, TLC-radioautography, HPLC, gas chromatography, and GC-mass spectroscopy. It appears that the major metabolic pathway of [14C]AI3-22641 resulted in ring opening of the furyl moiety to yield a saturated dihydroxy derivative.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalPesticide Biochemistry and Physiology
Volume25
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Biochemistry
  • Physiology

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