Distribution of SIV infection in the gastrointestinal tract of rhesus macaques at early and terminal stages of AIDS.

C. Heise, P. Vogel, Chris J Miller, A. Lackner, Satya Dandekar

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Intestinal tissues from SIV-infected rhesus macaques with subclinical as well as with terminal SIV disease were evaluated for SIV infection. SIV-infected mononuclear cells were detected throughout the gastrointestinal tract in all animals. In early infection, SIV-infected cells were diffusely distributed in lymphoid tissue and lamina propria, whereas in late stages of the disease, the viral infection was more severe and widely disseminated. Lymphoid cells of the lamina propria and gut-associated lymphoid tissue were the primary targets of SIV.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalJournal of Medical Primatology
Volume22
Issue number2-3
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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