Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: The amygdaloid complex

A. Pitkanen, David G Amaral

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The calcium-binding protein parvalbumin was immunohistochemically localized in the monkey amygdaloid complex. Parvalbumin-immunoreactive neuronal cell bodies, fibers, and terminals were observed in several amygdaloid nuclei and cortical areas. Three types of aspiny neurons, ranging from small spherical cells (Type 1) to large multipolar cells (Type 2) and fusiform cells (Type 3) were observed in most amygdaloid regions, though the proportions of the cell types were different in each region. The density of parvalbumin-immunoreactive fibers and terminals tended to parallel the density of labeled cell bodies. The highest densities of parvalbumin profiles were observed in the nucleus of the lateral olfactory tract, the periamygdaloid cortex (PAC2), the magnocellular division of the basal nucleus, the ventrolateral portion of the lateral nucleus, and the accessory basal nucleus. The regions containing the lowest densities of parvalbumin- positive profiles were the medial nucleus, anterior cortical nucleus, central nucleus, and the paralaminar nucleus. In regions with fiber and terminal labeling, pericellular networks of fibers, reminiscent of basket cell terminations, were commonly observed to surround unstained neuronal cell bodies and proximal dendrites. In the magnocellular division of the basal nucleus, and to a lesser extent in the lateral nucleus, parvalbumin-labeled 'cartridges' of axo-axonic terminals were observed on the initial segments of unlabeled cells. Parvalbumin-positive varicosities were also commonly observed in close apposition to the soma and dendrites of parvalbumin- immunoreactive cells. Given the close correspondence between the distribution of parvalbumin-positive neurons and a subset of GABAergic neurons in many brain regions, these data provide a first indication of the organization of the inhibitory circuitry of the primate amygdaloid complex.

Original languageEnglish (US)
Pages (from-to)14-36
Number of pages23
JournalJournal of Comparative Neurology
Volume331
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Parvalbumins
Temporal Lobe
Haplorhini
Basal Nucleus of Meynert
Dendrites
Neurons
GABAergic Neurons
Calcium-Binding Proteins
Carisoprodol
Primates

Keywords

  • amygdala
  • calcium-binding protein
  • immunohistochemistry
  • interneurons
  • primate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{3473d5006cfa47949985215c8f0c7e51,
title = "Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: The amygdaloid complex",
abstract = "The calcium-binding protein parvalbumin was immunohistochemically localized in the monkey amygdaloid complex. Parvalbumin-immunoreactive neuronal cell bodies, fibers, and terminals were observed in several amygdaloid nuclei and cortical areas. Three types of aspiny neurons, ranging from small spherical cells (Type 1) to large multipolar cells (Type 2) and fusiform cells (Type 3) were observed in most amygdaloid regions, though the proportions of the cell types were different in each region. The density of parvalbumin-immunoreactive fibers and terminals tended to parallel the density of labeled cell bodies. The highest densities of parvalbumin profiles were observed in the nucleus of the lateral olfactory tract, the periamygdaloid cortex (PAC2), the magnocellular division of the basal nucleus, the ventrolateral portion of the lateral nucleus, and the accessory basal nucleus. The regions containing the lowest densities of parvalbumin- positive profiles were the medial nucleus, anterior cortical nucleus, central nucleus, and the paralaminar nucleus. In regions with fiber and terminal labeling, pericellular networks of fibers, reminiscent of basket cell terminations, were commonly observed to surround unstained neuronal cell bodies and proximal dendrites. In the magnocellular division of the basal nucleus, and to a lesser extent in the lateral nucleus, parvalbumin-labeled 'cartridges' of axo-axonic terminals were observed on the initial segments of unlabeled cells. Parvalbumin-positive varicosities were also commonly observed in close apposition to the soma and dendrites of parvalbumin- immunoreactive cells. Given the close correspondence between the distribution of parvalbumin-positive neurons and a subset of GABAergic neurons in many brain regions, these data provide a first indication of the organization of the inhibitory circuitry of the primate amygdaloid complex.",
keywords = "amygdala, calcium-binding protein, immunohistochemistry, interneurons, primate",
author = "A. Pitkanen and Amaral, {David G}",
year = "1993",
language = "English (US)",
volume = "331",
pages = "14--36",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe

T2 - The amygdaloid complex

AU - Pitkanen, A.

AU - Amaral, David G

PY - 1993

Y1 - 1993

N2 - The calcium-binding protein parvalbumin was immunohistochemically localized in the monkey amygdaloid complex. Parvalbumin-immunoreactive neuronal cell bodies, fibers, and terminals were observed in several amygdaloid nuclei and cortical areas. Three types of aspiny neurons, ranging from small spherical cells (Type 1) to large multipolar cells (Type 2) and fusiform cells (Type 3) were observed in most amygdaloid regions, though the proportions of the cell types were different in each region. The density of parvalbumin-immunoreactive fibers and terminals tended to parallel the density of labeled cell bodies. The highest densities of parvalbumin profiles were observed in the nucleus of the lateral olfactory tract, the periamygdaloid cortex (PAC2), the magnocellular division of the basal nucleus, the ventrolateral portion of the lateral nucleus, and the accessory basal nucleus. The regions containing the lowest densities of parvalbumin- positive profiles were the medial nucleus, anterior cortical nucleus, central nucleus, and the paralaminar nucleus. In regions with fiber and terminal labeling, pericellular networks of fibers, reminiscent of basket cell terminations, were commonly observed to surround unstained neuronal cell bodies and proximal dendrites. In the magnocellular division of the basal nucleus, and to a lesser extent in the lateral nucleus, parvalbumin-labeled 'cartridges' of axo-axonic terminals were observed on the initial segments of unlabeled cells. Parvalbumin-positive varicosities were also commonly observed in close apposition to the soma and dendrites of parvalbumin- immunoreactive cells. Given the close correspondence between the distribution of parvalbumin-positive neurons and a subset of GABAergic neurons in many brain regions, these data provide a first indication of the organization of the inhibitory circuitry of the primate amygdaloid complex.

AB - The calcium-binding protein parvalbumin was immunohistochemically localized in the monkey amygdaloid complex. Parvalbumin-immunoreactive neuronal cell bodies, fibers, and terminals were observed in several amygdaloid nuclei and cortical areas. Three types of aspiny neurons, ranging from small spherical cells (Type 1) to large multipolar cells (Type 2) and fusiform cells (Type 3) were observed in most amygdaloid regions, though the proportions of the cell types were different in each region. The density of parvalbumin-immunoreactive fibers and terminals tended to parallel the density of labeled cell bodies. The highest densities of parvalbumin profiles were observed in the nucleus of the lateral olfactory tract, the periamygdaloid cortex (PAC2), the magnocellular division of the basal nucleus, the ventrolateral portion of the lateral nucleus, and the accessory basal nucleus. The regions containing the lowest densities of parvalbumin- positive profiles were the medial nucleus, anterior cortical nucleus, central nucleus, and the paralaminar nucleus. In regions with fiber and terminal labeling, pericellular networks of fibers, reminiscent of basket cell terminations, were commonly observed to surround unstained neuronal cell bodies and proximal dendrites. In the magnocellular division of the basal nucleus, and to a lesser extent in the lateral nucleus, parvalbumin-labeled 'cartridges' of axo-axonic terminals were observed on the initial segments of unlabeled cells. Parvalbumin-positive varicosities were also commonly observed in close apposition to the soma and dendrites of parvalbumin- immunoreactive cells. Given the close correspondence between the distribution of parvalbumin-positive neurons and a subset of GABAergic neurons in many brain regions, these data provide a first indication of the organization of the inhibitory circuitry of the primate amygdaloid complex.

KW - amygdala

KW - calcium-binding protein

KW - immunohistochemistry

KW - interneurons

KW - primate

UR - http://www.scopus.com/inward/record.url?scp=0027461435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027461435&partnerID=8YFLogxK

M3 - Article

C2 - 8320347

AN - SCOPUS:0027461435

VL - 331

SP - 14

EP - 36

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 1

ER -