TY - JOUR
T1 - Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet
AU - Ander, Bradley P.
AU - Edel, Andrea L.
AU - McCullough, Richelle
AU - Rodriguez-Leyva, Delfin
AU - Rampersad, Penelope
AU - Gilchrist, James S.C.
AU - Lukas, Anton
AU - Pierce, Grant N.
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Diets rich in omega-3 polyunsaturated fatty acids are associated with decreased incidences of cardiovascular disease. The extent of incorporation and distribution of these beneficial fats into body tissues is uncertain. Rabbits were fed regular rabbit chow or a diet containing 10% ground flaxseed that is highly enriched with the omega-3 polyunsaturated fatty acid α-linolenic acid (ALA). The high-flaxseed diet resulted in an incorporation of ALA in all tissues, but mostly in the heart and liver with little in the brain. Docosahexaenoic and eicosapentaenoic acid levels were also selectively increased in some tissues, and the effects were not as large as ALA. Arachidonic acid and the ratio of ω-6/ω-3 fatty acids were decreased in all tissues obtained from the flax-supplemented group. Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined.
AB - Diets rich in omega-3 polyunsaturated fatty acids are associated with decreased incidences of cardiovascular disease. The extent of incorporation and distribution of these beneficial fats into body tissues is uncertain. Rabbits were fed regular rabbit chow or a diet containing 10% ground flaxseed that is highly enriched with the omega-3 polyunsaturated fatty acid α-linolenic acid (ALA). The high-flaxseed diet resulted in an incorporation of ALA in all tissues, but mostly in the heart and liver with little in the brain. Docosahexaenoic and eicosapentaenoic acid levels were also selectively increased in some tissues, and the effects were not as large as ALA. Arachidonic acid and the ratio of ω-6/ω-3 fatty acids were decreased in all tissues obtained from the flax-supplemented group. Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined.
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U2 - 10.1016/j.metabol.2009.09.005
DO - 10.1016/j.metabol.2009.09.005
M3 - Article
C2 - 19913851
AN - SCOPUS:77950825063
VL - 59
SP - 620
EP - 627
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 5
ER -