Distribution of genetic diversity in relation to chromosomal inversions in the malaria mosquito Anopheles gambiae

K. D. Mathiopoulos, Gregory C Lanzaro

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The epidemiology of malaria in Africa is complicated by the fact that its principal vector, the mosquito Anopheles gambiae, constitutes a complex of six sibling species. Each species is characterized by a unique array of paracentric inversions, as deduced by karyotypic analysis. In addition, most of the species carry a number of polymorphic inversions. In order to develop an under standing of the evolutionary histories of different pans of the genome, we compared the genetic variation of areas inside and outside inversions in two distinct inversion karyotypes of A. gambiae. Thirty-five cDNA clones were mapped on the five arms of the A. gambiae chromosomes with divisional probes. Sixteen of these clones, localized both inside and outside inversions of chromosome 2, were used as probes in order to determine the nucleotide diversity of different pans of the genome in the two inversion karyotypes. We observed that the sequence diversity inside the inversion is more than threefold lower than in areas outside the inversion and that the degree of divergence increases gradually at loci at increasing distance from the inversion. To interpret the data we present a selectionist and a stochastic model, both of which point to a relatively recent origin of the studied inversion and may suggest differences between the evolutionary history of inversions in Anopheles and Drosophila species.

Original languageEnglish (US)
Pages (from-to)578-584
Number of pages7
JournalJournal of Molecular Evolution
Volume40
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Hitchhiking
  • Inversion evolution
  • Linked gene complex
  • Nucleotide diversity
  • Selective sweep

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

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