Distribution of Flunixin Meglumine and Firocoxib into Aqueous Humor of Horses

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Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used systemically for the treatment of inflammatory ocular disease in horses. However, little information exists regarding the ocular penetration of this class of drugs in the horse. Objective: To determine the distribution of orally administered flunixin meglumine and firocoxib into the aqueous humor of horses. Animals: Fifteen healthy adult horses with no evidence of ophthalmic disease. Methods: Horses were randomly assigned to a control group and 2 treatment groups of equal sizes (n = 5). Horses assigned to the treatment groups received an NSAID (flunixin meglumine, 1.1mg/kg PO q24h or firocoxib, 0.1mg/kg PO q24h for 7 days). Horses in the control group received no medications. Concentrations of flunixin meglumine and firocoxib in serum and aqueous humor and prostaglandin (PG) E 2 in aqueous humor were determined on days 1, 3, and 5 and aqueous:serum ratios were calculated. Results: Firocoxib penetrated the aqueous humor to a significantly greater extent than did flunixin meglumine at days 3 and 5. Aqueous:serum ratios were 3.59 ± 3.32 and 11.99 ± 4.62% for flunixin meglumine and firocoxib, respectively. Ocular PGE 2 concentrations showed no differences at any time point among study groups. Conclusions and Clinical Importance: Both flunixin meglumine and firocoxib penetrated into the aqueous humor of horses. This study suggests that orally administered firocoxib penetrates the aqueous humor better than orally administered flunixin meglumine at label dosages in the absence of ocular inflammation. Firocoxib should be considered for the treatment of inflammatory ophthalmic lesions in horses at risk for the development of adverse effects associated with nonselective NSAID administration.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalJournal of Veterinary Internal Medicine
Volume25
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

flunixin
Aqueous Humor
Horses
horses
water
nonsteroidal anti-inflammatory agents
eyes
eye diseases
Anti-Inflammatory Agents
Eye Diseases
Prostaglandins E
Pharmaceutical Preparations
Serum
flunixin meglumine
firocoxib
Control Groups
Therapeutics
group size
lesions (animal)
prostaglandins

Keywords

  • Cyclooxygenase
  • NSAID
  • Ophthalmology
  • Uveitis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{d9b8c49eb4114ad6a877d35f0c5d00aa,
title = "Distribution of Flunixin Meglumine and Firocoxib into Aqueous Humor of Horses",
abstract = "Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used systemically for the treatment of inflammatory ocular disease in horses. However, little information exists regarding the ocular penetration of this class of drugs in the horse. Objective: To determine the distribution of orally administered flunixin meglumine and firocoxib into the aqueous humor of horses. Animals: Fifteen healthy adult horses with no evidence of ophthalmic disease. Methods: Horses were randomly assigned to a control group and 2 treatment groups of equal sizes (n = 5). Horses assigned to the treatment groups received an NSAID (flunixin meglumine, 1.1mg/kg PO q24h or firocoxib, 0.1mg/kg PO q24h for 7 days). Horses in the control group received no medications. Concentrations of flunixin meglumine and firocoxib in serum and aqueous humor and prostaglandin (PG) E 2 in aqueous humor were determined on days 1, 3, and 5 and aqueous:serum ratios were calculated. Results: Firocoxib penetrated the aqueous humor to a significantly greater extent than did flunixin meglumine at days 3 and 5. Aqueous:serum ratios were 3.59 ± 3.32 and 11.99 ± 4.62{\%} for flunixin meglumine and firocoxib, respectively. Ocular PGE 2 concentrations showed no differences at any time point among study groups. Conclusions and Clinical Importance: Both flunixin meglumine and firocoxib penetrated into the aqueous humor of horses. This study suggests that orally administered firocoxib penetrates the aqueous humor better than orally administered flunixin meglumine at label dosages in the absence of ocular inflammation. Firocoxib should be considered for the treatment of inflammatory ophthalmic lesions in horses at risk for the development of adverse effects associated with nonselective NSAID administration.",
keywords = "Cyclooxygenase, NSAID, Ophthalmology, Uveitis",
author = "Hilton, {H. G.} and Magdesian, {K G} and Groth, {A. D.} and Knych, {Heather K} and Stanley, {Scott D} and Hollingsworth, {Steven R}",
year = "2011",
month = "9",
doi = "10.1111/j.1939-1676.2011.0763.x",
language = "English (US)",
volume = "25",
pages = "1127--1133",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Distribution of Flunixin Meglumine and Firocoxib into Aqueous Humor of Horses

AU - Hilton, H. G.

AU - Magdesian, K G

AU - Groth, A. D.

AU - Knych, Heather K

AU - Stanley, Scott D

AU - Hollingsworth, Steven R

PY - 2011/9

Y1 - 2011/9

N2 - Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used systemically for the treatment of inflammatory ocular disease in horses. However, little information exists regarding the ocular penetration of this class of drugs in the horse. Objective: To determine the distribution of orally administered flunixin meglumine and firocoxib into the aqueous humor of horses. Animals: Fifteen healthy adult horses with no evidence of ophthalmic disease. Methods: Horses were randomly assigned to a control group and 2 treatment groups of equal sizes (n = 5). Horses assigned to the treatment groups received an NSAID (flunixin meglumine, 1.1mg/kg PO q24h or firocoxib, 0.1mg/kg PO q24h for 7 days). Horses in the control group received no medications. Concentrations of flunixin meglumine and firocoxib in serum and aqueous humor and prostaglandin (PG) E 2 in aqueous humor were determined on days 1, 3, and 5 and aqueous:serum ratios were calculated. Results: Firocoxib penetrated the aqueous humor to a significantly greater extent than did flunixin meglumine at days 3 and 5. Aqueous:serum ratios were 3.59 ± 3.32 and 11.99 ± 4.62% for flunixin meglumine and firocoxib, respectively. Ocular PGE 2 concentrations showed no differences at any time point among study groups. Conclusions and Clinical Importance: Both flunixin meglumine and firocoxib penetrated into the aqueous humor of horses. This study suggests that orally administered firocoxib penetrates the aqueous humor better than orally administered flunixin meglumine at label dosages in the absence of ocular inflammation. Firocoxib should be considered for the treatment of inflammatory ophthalmic lesions in horses at risk for the development of adverse effects associated with nonselective NSAID administration.

AB - Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used systemically for the treatment of inflammatory ocular disease in horses. However, little information exists regarding the ocular penetration of this class of drugs in the horse. Objective: To determine the distribution of orally administered flunixin meglumine and firocoxib into the aqueous humor of horses. Animals: Fifteen healthy adult horses with no evidence of ophthalmic disease. Methods: Horses were randomly assigned to a control group and 2 treatment groups of equal sizes (n = 5). Horses assigned to the treatment groups received an NSAID (flunixin meglumine, 1.1mg/kg PO q24h or firocoxib, 0.1mg/kg PO q24h for 7 days). Horses in the control group received no medications. Concentrations of flunixin meglumine and firocoxib in serum and aqueous humor and prostaglandin (PG) E 2 in aqueous humor were determined on days 1, 3, and 5 and aqueous:serum ratios were calculated. Results: Firocoxib penetrated the aqueous humor to a significantly greater extent than did flunixin meglumine at days 3 and 5. Aqueous:serum ratios were 3.59 ± 3.32 and 11.99 ± 4.62% for flunixin meglumine and firocoxib, respectively. Ocular PGE 2 concentrations showed no differences at any time point among study groups. Conclusions and Clinical Importance: Both flunixin meglumine and firocoxib penetrated into the aqueous humor of horses. This study suggests that orally administered firocoxib penetrates the aqueous humor better than orally administered flunixin meglumine at label dosages in the absence of ocular inflammation. Firocoxib should be considered for the treatment of inflammatory ophthalmic lesions in horses at risk for the development of adverse effects associated with nonselective NSAID administration.

KW - Cyclooxygenase

KW - NSAID

KW - Ophthalmology

KW - Uveitis

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U2 - 10.1111/j.1939-1676.2011.0763.x

DO - 10.1111/j.1939-1676.2011.0763.x

M3 - Article

VL - 25

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EP - 1133

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

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