Distribution of dietary limiting amino acid injected into the prepyriform cortex

J. L. Beverly, B. J. Hrupka, D. W. Gietzen, Quinton Rogers

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Diffusion or metabolism of the dietary limiting amino acid (DLAA) in the prepyriform cortex (PPC) may account for the time lag between injection of the DLAA into the PPC and the increase in intake of an amino acid-imbalanced diet. Results from the injection of [3H]Leu ± [14C]Thr (DLAA) into the PPC indicated rapid (<15 min) and limited diffusion (85-90% of recovered label was ≤1 mm from the injection site). 3H and 14C decreased in the trichloroacetic acid (TCA)-soluble fraction and increased in the TCA-insoluble fraction during the first 1.5 h and remained constant in the TCA-insoluble fraction 1.5-6 h after injection. An increase (~50%) in 3H in the TCA-insoluble fraction was found ≤30 min after injection of the DLAA. There was no affect of the DLAA on 3H in the TCA-soluble fraction. These results indicated that a change in metabolism within the PPC may be responsible for the delay in onset of the feeding response after injection of the DLAA into the PPC.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number3 29-3
StatePublished - Jan 1 1991


  • Amino acid imbalance
  • Food intake regulation
  • Protein synthesis

ASJC Scopus subject areas

  • Physiology


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