Distribution and size of mucous glands in the ferret tracheobronchial tree

Mohammad Hajighasemi-Ossareh, Rachel M. Borthwell, Jeremy E. Stevens, Walter E. Finkbeiner, Jonathan Widdicombe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A transgenic ferret model of cystic fibrosis has recently been generated. It is probable that malfunction of airway mucous glands contributes significantly to the airway pathology of this disease. The usefulness of the ferret model may therefore depend in part on how closely the airway glands of ferrets resemble those of humans. Here, we show that in the ferret trachea glands are commonest in its most ventral aspect and disappear about half way up the lateral walls; they are virtually absent from the dorsal membranous portion. Further, the aggregate volume of glands per unit mucosal surface declines progressively by about 60% between the larynx and the carina. The average frequency of glands openings for the ferret trachea as a whole is only about one-fifth that in humans (where gland openings are found at approximately the same frequency throughout the trachea). Glands in the ferret trachea are on average about one-third the size of those in the human. Therefore, the aggregate volume of tracheal glands (per unit mucosal surface area) in the ferret is only about 6% that in humans. As in other mammalian species, airway glands in the ferret disappear at an airway internal diameter of ~1 mm, corresponding approximately in this species to airway generation 6.

Original languageEnglish (US)
Pages (from-to)1768-1774
Number of pages7
JournalAnatomical Record
Volume296
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Ferrets
ferrets
trachea (vertebrates)
pathology
Trachea
surface area
larynx
distribution
cystic fibrosis
Larynx
Cystic Fibrosis
genetically modified organisms
Pathology

Keywords

  • Airway mucous gland
  • Cystic fibrosis
  • Ferret

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

Cite this

Hajighasemi-Ossareh, M., Borthwell, R. M., Stevens, J. E., Finkbeiner, W. E., & Widdicombe, J. (2013). Distribution and size of mucous glands in the ferret tracheobronchial tree. Anatomical Record, 296(11), 1768-1774. https://doi.org/10.1002/ar.22783

Distribution and size of mucous glands in the ferret tracheobronchial tree. / Hajighasemi-Ossareh, Mohammad; Borthwell, Rachel M.; Stevens, Jeremy E.; Finkbeiner, Walter E.; Widdicombe, Jonathan.

In: Anatomical Record, Vol. 296, No. 11, 11.2013, p. 1768-1774.

Research output: Contribution to journalArticle

Hajighasemi-Ossareh, M, Borthwell, RM, Stevens, JE, Finkbeiner, WE & Widdicombe, J 2013, 'Distribution and size of mucous glands in the ferret tracheobronchial tree', Anatomical Record, vol. 296, no. 11, pp. 1768-1774. https://doi.org/10.1002/ar.22783
Hajighasemi-Ossareh M, Borthwell RM, Stevens JE, Finkbeiner WE, Widdicombe J. Distribution and size of mucous glands in the ferret tracheobronchial tree. Anatomical Record. 2013 Nov;296(11):1768-1774. https://doi.org/10.1002/ar.22783
Hajighasemi-Ossareh, Mohammad ; Borthwell, Rachel M. ; Stevens, Jeremy E. ; Finkbeiner, Walter E. ; Widdicombe, Jonathan. / Distribution and size of mucous glands in the ferret tracheobronchial tree. In: Anatomical Record. 2013 ; Vol. 296, No. 11. pp. 1768-1774.
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