Distribution and Assembly of TRP Ion Channels

Wei Cheng, Jie Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In the last several decades, a large family of ion channels have been identified and studied intensively as cellular sensors for diverse physical and/or chemical stimuli. Named transient receptor potential (TRP) channels, they play critical roles in various aspects of cellular physiology. A large number of human hereditary diseases are found to be linked to TRP channel mutations, and their dysregulations lead to acute or chronical health problems. As TRP channels are named and categorized mostly based on sequence homology rather than functional similarities, they exhibit substantial functional diversity. Rapid advances in TRP channel study have been made in recent years and reported in a vast body of literature; a summary of the latest advancements becomes necessary. This chapter offers an overview of current understandings of TRP channel distribution and subunit assembly.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages111-138
Number of pages28
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1349
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Channelopathy
  • Heteromultimer
  • Homomultimer
  • Mutation
  • Protein complex
  • Trafficking

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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