Distinctive RNA expression profiles in blood associated with alzheimer disease after accounting for white matter hyperintensities

Zhouxian Bai, Boryana Stamova, Huichun Xu, Bradley Ander, Jiajia Wang, Glen C. Jickling, Xinhua Zhan, Da Liu, Guangchun Han, Lee-Way Jin, Charles DeCarli, Hongxing Lei, Frank R Sharp

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

BACKGROUND:: Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. METHODS:: RNA from whole blood was processed on whole-genome microarrays. RESULTS:: A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2. CONCLUSIONS:: RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.

Original languageEnglish (US)
Pages (from-to)226-233
Number of pages8
JournalAlzheimer Disease and Associated Disorders
Volume28
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Alzheimer disease
  • blood
  • brain
  • RNA
  • white matter hyperintensities

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

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