Distinct potassium channels on pain-sensing neurons

Matthew N. Rasband, Eunice W. Park, Todd W. Vanderah, Josephine Lai, Frank Porreca, James Trimmer

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model of neuropathic pain leads to striking reductions in voltage-gated K+ (Kv) channel subunit expression in dorsal root ganglia (DRG) neurons, suggesting a potential molecular mechanism for hyperexcitability of injured nerves. Moreover, specific classes of DRG neurons express distinct Kv channel subunit combinations. Importantly, Kv1.4 is the sole Kv1 α subunit expressed in smaller diameter neurons, suggesting that homomeric Kv1.4 channels predominate in Aδ and C fibers arising from these cells. These neurons are presumably nociceptors, because they also express the VR-1 capsaicin receptor, calcitonin gene-related peptide, and/or Na+ channel SNS/PN3/Nav1.8. In contrast, larger diameter neurons associated with mechanoreception and proprioception express high levels of Kv1.1 and Kv1.2 without Kv1.4 or other Kv1 α subunits, suggesting that heteromers of these subunits predominate on large, myelinated afferent axons that extend from these cells.

Original languageEnglish (US)
Pages (from-to)13373-13378
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number23
DOIs
StatePublished - Nov 6 2001
Externally publishedYes

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Potassium Channels
Neurons
Pain
Spinal Ganglia
Voltage-Gated Potassium Channels
TRPV Cation Channels
Myelinated Nerve Fibers
Proprioception
Unmyelinated Nerve Fibers
Nociceptors
Calcitonin Gene-Related Peptide
Neuralgia
Sensory Receptor Cells
Ion Channels
Axons
Wounds and Injuries

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Rasband, M. N., Park, E. W., Vanderah, T. W., Lai, J., Porreca, F., & Trimmer, J. (2001). Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America, 98(23), 13373-13378. https://doi.org/10.1073/pnas.231376298

Distinct potassium channels on pain-sensing neurons. / Rasband, Matthew N.; Park, Eunice W.; Vanderah, Todd W.; Lai, Josephine; Porreca, Frank; Trimmer, James.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 23, 06.11.2001, p. 13373-13378.

Research output: Contribution to journalArticle

Rasband, MN, Park, EW, Vanderah, TW, Lai, J, Porreca, F & Trimmer, J 2001, 'Distinct potassium channels on pain-sensing neurons', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 23, pp. 13373-13378. https://doi.org/10.1073/pnas.231376298
Rasband, Matthew N. ; Park, Eunice W. ; Vanderah, Todd W. ; Lai, Josephine ; Porreca, Frank ; Trimmer, James. / Distinct potassium channels on pain-sensing neurons. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 23. pp. 13373-13378.
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