Distinct memory cd4+ t cells with commitment to t follicular helper- and t helper 1-cell lineages are generated after acute viral infection

J. Scott Hale, Ben Youngblood, Donald R. Latner, Ata Ur Rasheed Mohammed, Lilin Ye, Rama S. Akondy, Tuoqi Wu, Smita Iyer, Rafi Ahmed

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

CD4+ T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh cell lineage after antigen clearance. By using adoptive transfer of antigen-specific memory CD4+ T cell subpopulations in the lymphocytic choriomeningitis virus infection model, we found that there are distinct memory CD4+ T cell populations with commitment to either Tfh- or Th1-cell lineages. Our conclusions are based on gene expression profiles, epigenetic studies, and phenotypic and functional analyses. Our findings indicate that CD4+ memory T cells " remember" their previous effector lineage after antigen clearance, being poised to reacquire their lineage-specific effector functions upon antigen reencounter. These findings have important implications for rational vaccine design, where improving the generation and engagement of memory Tfh cells could be used to enhance vaccine-induced protective immunity.

Original languageEnglish (US)
Pages (from-to)805-817
Number of pages13
JournalImmunity
Volume38
Issue number4
DOIs
StatePublished - Apr 18 2013
Externally publishedYes

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Cell Lineage
Virus Diseases
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Antigens
Vaccines
Lymphocytic choriomeningitis virus
Th1 Cells
Germinal Center
Adoptive Transfer
Transcriptome
Epigenomics
Antibody Formation
Immunity
B-Lymphocytes
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Hale, J. S., Youngblood, B., Latner, D. R., Mohammed, A. U. R., Ye, L., Akondy, R. S., ... Ahmed, R. (2013). Distinct memory cd4+ t cells with commitment to t follicular helper- and t helper 1-cell lineages are generated after acute viral infection. Immunity, 38(4), 805-817. https://doi.org/10.1016/j.immuni.2013.02.020

Distinct memory cd4+ t cells with commitment to t follicular helper- and t helper 1-cell lineages are generated after acute viral infection. / Hale, J. Scott; Youngblood, Ben; Latner, Donald R.; Mohammed, Ata Ur Rasheed; Ye, Lilin; Akondy, Rama S.; Wu, Tuoqi; Iyer, Smita; Ahmed, Rafi.

In: Immunity, Vol. 38, No. 4, 18.04.2013, p. 805-817.

Research output: Contribution to journalArticle

Hale, JS, Youngblood, B, Latner, DR, Mohammed, AUR, Ye, L, Akondy, RS, Wu, T, Iyer, S & Ahmed, R 2013, 'Distinct memory cd4+ t cells with commitment to t follicular helper- and t helper 1-cell lineages are generated after acute viral infection', Immunity, vol. 38, no. 4, pp. 805-817. https://doi.org/10.1016/j.immuni.2013.02.020
Hale, J. Scott ; Youngblood, Ben ; Latner, Donald R. ; Mohammed, Ata Ur Rasheed ; Ye, Lilin ; Akondy, Rama S. ; Wu, Tuoqi ; Iyer, Smita ; Ahmed, Rafi. / Distinct memory cd4+ t cells with commitment to t follicular helper- and t helper 1-cell lineages are generated after acute viral infection. In: Immunity. 2013 ; Vol. 38, No. 4. pp. 805-817.
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