Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD Rio Mycobacterium tuberculosis sublineage

Scott A. Weisenberg, Andrea L. Gibson, Richard C. Huard, Natalia Kurepina, Heejung Bang, Luiz C O Lazzarini, Yalin Chiu, Jiehui Li, Shama Ahuja, Jeff Driscoll, Barry N. Kreiswirth, John L. Ho

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Genetic tracking of Mycobacterium tuberculosis is a cornerstone of tuberculosis (TB) control programs. The RD Rio M. tuberculosis sublineage was previously associated with TB in Brazil. We investigated 3847 M. tuberculosis isolates and registry data from New York City (NYC) (2001-2005) to: (1) affirm the position of RD Rio strains within the M. tuberculosis phylogenetic structure, (2) determine its prevalence, and (3) define transmission, demographic, and clinical characteristics associated with RD Rio TB. Methods: Isolates classified as RD Rio or non-RD Rio M. tuberculosis by multiplex PCR were further classified as clustered (≥2 isolates) or unique based primarily upon IS6110-RFLP patterns and lineage-specific cluster proportions were calculated. The secondary case rate of RD Rio was compared with other prevalent M. tuberculosis lineages. Genotype data were merged with the data from the NYC TB Registry to assess demographic and clinical characteristics. Results: RD Rio strains were found to: (1) be restricted to the Latin American-Mediterranean family, (2) cause approximately 8% of TB cases in NYC, and (3) be associated with heightened transmission as shown by: (i) a higher cluster proportion compared to other prevalent lineages, (ii) a higher secondary case rate, and (iii) cases in children. Furthermore, RD Rio strains were significantly associated with US-born Black or Hispanic race, birth in Latin American and Caribbean countries, and isoniazid resistance. Conclusions: The RD Rio genotype is a single M. tuberculosis strain population that is emerging in NYC. The findings suggest that expanded RD Rio case and exposure identification could be of benefit due to its association with heightened transmission.

Original languageEnglish (US)
Pages (from-to)664-670
Number of pages7
JournalInfection, Genetics and Evolution
Volume12
Issue number4
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

tuberculosis
Mycobacterium tuberculosis
Tuberculosis
Registries
demographic statistics
Genotype
Demography
isoniazid
genotype
Multiplex Polymerase Chain Reaction
Isoniazid
city
Hispanic Americans
Restriction Fragment Length Polymorphisms
genetic background
Brazil
restriction fragment length polymorphism
Parturition
phylogeny
Population

Keywords

  • Epidemiology
  • Lineage
  • RD
  • Transmission
  • Tuberculosis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD Rio Mycobacterium tuberculosis sublineage. / Weisenberg, Scott A.; Gibson, Andrea L.; Huard, Richard C.; Kurepina, Natalia; Bang, Heejung; Lazzarini, Luiz C O; Chiu, Yalin; Li, Jiehui; Ahuja, Shama; Driscoll, Jeff; Kreiswirth, Barry N.; Ho, John L.

In: Infection, Genetics and Evolution, Vol. 12, No. 4, 06.2012, p. 664-670.

Research output: Contribution to journalArticle

Weisenberg, SA, Gibson, AL, Huard, RC, Kurepina, N, Bang, H, Lazzarini, LCO, Chiu, Y, Li, J, Ahuja, S, Driscoll, J, Kreiswirth, BN & Ho, JL 2012, 'Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD Rio Mycobacterium tuberculosis sublineage', Infection, Genetics and Evolution, vol. 12, no. 4, pp. 664-670. https://doi.org/10.1016/j.meegid.2011.07.018
Weisenberg, Scott A. ; Gibson, Andrea L. ; Huard, Richard C. ; Kurepina, Natalia ; Bang, Heejung ; Lazzarini, Luiz C O ; Chiu, Yalin ; Li, Jiehui ; Ahuja, Shama ; Driscoll, Jeff ; Kreiswirth, Barry N. ; Ho, John L. / Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD Rio Mycobacterium tuberculosis sublineage. In: Infection, Genetics and Evolution. 2012 ; Vol. 12, No. 4. pp. 664-670.
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abstract = "Background: Genetic tracking of Mycobacterium tuberculosis is a cornerstone of tuberculosis (TB) control programs. The RD Rio M. tuberculosis sublineage was previously associated with TB in Brazil. We investigated 3847 M. tuberculosis isolates and registry data from New York City (NYC) (2001-2005) to: (1) affirm the position of RD Rio strains within the M. tuberculosis phylogenetic structure, (2) determine its prevalence, and (3) define transmission, demographic, and clinical characteristics associated with RD Rio TB. Methods: Isolates classified as RD Rio or non-RD Rio M. tuberculosis by multiplex PCR were further classified as clustered (≥2 isolates) or unique based primarily upon IS6110-RFLP patterns and lineage-specific cluster proportions were calculated. The secondary case rate of RD Rio was compared with other prevalent M. tuberculosis lineages. Genotype data were merged with the data from the NYC TB Registry to assess demographic and clinical characteristics. Results: RD Rio strains were found to: (1) be restricted to the Latin American-Mediterranean family, (2) cause approximately 8{\%} of TB cases in NYC, and (3) be associated with heightened transmission as shown by: (i) a higher cluster proportion compared to other prevalent lineages, (ii) a higher secondary case rate, and (iii) cases in children. Furthermore, RD Rio strains were significantly associated with US-born Black or Hispanic race, birth in Latin American and Caribbean countries, and isoniazid resistance. Conclusions: The RD Rio genotype is a single M. tuberculosis strain population that is emerging in NYC. The findings suggest that expanded RD Rio case and exposure identification could be of benefit due to its association with heightened transmission.",
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T1 - Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD Rio Mycobacterium tuberculosis sublineage

AU - Weisenberg, Scott A.

AU - Gibson, Andrea L.

AU - Huard, Richard C.

AU - Kurepina, Natalia

AU - Bang, Heejung

AU - Lazzarini, Luiz C O

AU - Chiu, Yalin

AU - Li, Jiehui

AU - Ahuja, Shama

AU - Driscoll, Jeff

AU - Kreiswirth, Barry N.

AU - Ho, John L.

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N2 - Background: Genetic tracking of Mycobacterium tuberculosis is a cornerstone of tuberculosis (TB) control programs. The RD Rio M. tuberculosis sublineage was previously associated with TB in Brazil. We investigated 3847 M. tuberculosis isolates and registry data from New York City (NYC) (2001-2005) to: (1) affirm the position of RD Rio strains within the M. tuberculosis phylogenetic structure, (2) determine its prevalence, and (3) define transmission, demographic, and clinical characteristics associated with RD Rio TB. Methods: Isolates classified as RD Rio or non-RD Rio M. tuberculosis by multiplex PCR were further classified as clustered (≥2 isolates) or unique based primarily upon IS6110-RFLP patterns and lineage-specific cluster proportions were calculated. The secondary case rate of RD Rio was compared with other prevalent M. tuberculosis lineages. Genotype data were merged with the data from the NYC TB Registry to assess demographic and clinical characteristics. Results: RD Rio strains were found to: (1) be restricted to the Latin American-Mediterranean family, (2) cause approximately 8% of TB cases in NYC, and (3) be associated with heightened transmission as shown by: (i) a higher cluster proportion compared to other prevalent lineages, (ii) a higher secondary case rate, and (iii) cases in children. Furthermore, RD Rio strains were significantly associated with US-born Black or Hispanic race, birth in Latin American and Caribbean countries, and isoniazid resistance. Conclusions: The RD Rio genotype is a single M. tuberculosis strain population that is emerging in NYC. The findings suggest that expanded RD Rio case and exposure identification could be of benefit due to its association with heightened transmission.

AB - Background: Genetic tracking of Mycobacterium tuberculosis is a cornerstone of tuberculosis (TB) control programs. The RD Rio M. tuberculosis sublineage was previously associated with TB in Brazil. We investigated 3847 M. tuberculosis isolates and registry data from New York City (NYC) (2001-2005) to: (1) affirm the position of RD Rio strains within the M. tuberculosis phylogenetic structure, (2) determine its prevalence, and (3) define transmission, demographic, and clinical characteristics associated with RD Rio TB. Methods: Isolates classified as RD Rio or non-RD Rio M. tuberculosis by multiplex PCR were further classified as clustered (≥2 isolates) or unique based primarily upon IS6110-RFLP patterns and lineage-specific cluster proportions were calculated. The secondary case rate of RD Rio was compared with other prevalent M. tuberculosis lineages. Genotype data were merged with the data from the NYC TB Registry to assess demographic and clinical characteristics. Results: RD Rio strains were found to: (1) be restricted to the Latin American-Mediterranean family, (2) cause approximately 8% of TB cases in NYC, and (3) be associated with heightened transmission as shown by: (i) a higher cluster proportion compared to other prevalent lineages, (ii) a higher secondary case rate, and (iii) cases in children. Furthermore, RD Rio strains were significantly associated with US-born Black or Hispanic race, birth in Latin American and Caribbean countries, and isoniazid resistance. Conclusions: The RD Rio genotype is a single M. tuberculosis strain population that is emerging in NYC. The findings suggest that expanded RD Rio case and exposure identification could be of benefit due to its association with heightened transmission.

KW - Epidemiology

KW - Lineage

KW - RD

KW - Transmission

KW - Tuberculosis

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