Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis

Research output: Contribution to journalArticle

247 Citations (Scopus)

Abstract

Neocortical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of diverse cortical cell types. In Drosophila, cleavage plane orientation dictates the inheritance of fate-determinants and the symmetry of newborn daughter cells during neuroblast cell divisions. One model for predicting daughter cell fate in the mammalian neocortex is also based on cleavage plane orientation. Precursor cell divisions with a cleavage plane orientation that is perpendicular with respect to the ventricular surface (vertical) are predicted to be symmetric, while divisions with a cleavage plane orientation that is parallel to the surface (horizontal) are predicted to be asymmetric neurogenic divisions. However, analysis of cleavage plane orientation at the ventricle suggests that the number of predicted neurogenic divisions might be insufficient to produce large amounts of cortical neurons. To understand factors that correlate with the symmetry of cell divisions, we examined rat neocortical precursor cells in situ through real-time imaging, marker analysis, and electrophysiological recordings. We find that cleavage plane orientation is more closely associated with precursor cell type than with daughter cell fate, as commonly thought. Radial glia cells in the VZ primarily divide with a vertical orientation throughout cortical development and undergo symmetric or asymmetric self-renewing divisions depending on the stage of development. In contrast, most intermediate progenitor cells divide in the subventricular zone with a horizontal orientation and produce symmetric daughter cells. We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants.

Original languageEnglish (US)
Pages (from-to)28-44
Number of pages17
JournalJournal of Comparative Neurology
Volume508
Issue number1
DOIs
StatePublished - May 1 2008

Fingerprint

Neural Stem Cells
Neurogenesis
Stem Cells
Cell Division
Lateral Ventricles
Neocortex
Neuroglia
Drosophila
Neurons

Keywords

  • Asymmetric division
  • Cleavage plane
  • Cortical development
  • Intermediate progenitor cells
  • Mitosis
  • Neural stem cells
  • Neurogenesis
  • Precursor cells
  • Radial glial cells
  • Self-renewal
  • Subventricular zone
  • Symmetric division
  • Ventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis. / Noctor, Stephen C; Martinez-Cerdeno, Veronica; Kriegstein, Arnold R.

In: Journal of Comparative Neurology, Vol. 508, No. 1, 01.05.2008, p. 28-44.

Research output: Contribution to journalArticle

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