Dissolution of gallstones using methyl tertiary-butyl ether in an animal model

John P McGahan, H. Tesluk, J. M. Brook, R. Johnston, D. B. Shaul

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Human gallstones were surgically implanted in the gallbladders of six pigs. Through cholecystostomy catheters, methyl tertiary-butyl ether (MTBE) was infused from 3 to 5 days. MTBE successfully dissolved 19 of the 20 cholesterol stones and partially dissolved one mixed cholesterol-bilirubin stone. Gross and microscopic examination of abdominal organs revealed mild superficial ulcerations of the gallbladder and mild to moderate chronic inflammatory changes in the gallbladder of animals treated with MTBE infusion. There were no other significant changes within other abdominal organs except for mild inflammation of the duodenum in one animal and of the common bile duct in another. Because of its efficacy and limited deleterious effects, MTBE may be a good solvent when dissolving pure cholesterol gallstones in the gallbladder.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalInvestigative Radiology
Volume23
Issue number8
StatePublished - 1988

Fingerprint

Gallstones
Gallbladder
Ether
Animal Models
Cholesterol
Cholecystostomy
Common Bile Duct
Duodenum
Bilirubin
Swine
Catheters
Inflammation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

McGahan, J. P., Tesluk, H., Brook, J. M., Johnston, R., & Shaul, D. B. (1988). Dissolution of gallstones using methyl tertiary-butyl ether in an animal model. Investigative Radiology, 23(8), 599-603.

Dissolution of gallstones using methyl tertiary-butyl ether in an animal model. / McGahan, John P; Tesluk, H.; Brook, J. M.; Johnston, R.; Shaul, D. B.

In: Investigative Radiology, Vol. 23, No. 8, 1988, p. 599-603.

Research output: Contribution to journalArticle

McGahan, JP, Tesluk, H, Brook, JM, Johnston, R & Shaul, DB 1988, 'Dissolution of gallstones using methyl tertiary-butyl ether in an animal model', Investigative Radiology, vol. 23, no. 8, pp. 599-603.
McGahan, John P ; Tesluk, H. ; Brook, J. M. ; Johnston, R. ; Shaul, D. B. / Dissolution of gallstones using methyl tertiary-butyl ether in an animal model. In: Investigative Radiology. 1988 ; Vol. 23, No. 8. pp. 599-603.
@article{2930e2cbcb0e47dd8393514dadeed032,
title = "Dissolution of gallstones using methyl tertiary-butyl ether in an animal model",
abstract = "Human gallstones were surgically implanted in the gallbladders of six pigs. Through cholecystostomy catheters, methyl tertiary-butyl ether (MTBE) was infused from 3 to 5 days. MTBE successfully dissolved 19 of the 20 cholesterol stones and partially dissolved one mixed cholesterol-bilirubin stone. Gross and microscopic examination of abdominal organs revealed mild superficial ulcerations of the gallbladder and mild to moderate chronic inflammatory changes in the gallbladder of animals treated with MTBE infusion. There were no other significant changes within other abdominal organs except for mild inflammation of the duodenum in one animal and of the common bile duct in another. Because of its efficacy and limited deleterious effects, MTBE may be a good solvent when dissolving pure cholesterol gallstones in the gallbladder.",
author = "McGahan, {John P} and H. Tesluk and Brook, {J. M.} and R. Johnston and Shaul, {D. B.}",
year = "1988",
language = "English (US)",
volume = "23",
pages = "599--603",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Dissolution of gallstones using methyl tertiary-butyl ether in an animal model

AU - McGahan, John P

AU - Tesluk, H.

AU - Brook, J. M.

AU - Johnston, R.

AU - Shaul, D. B.

PY - 1988

Y1 - 1988

N2 - Human gallstones were surgically implanted in the gallbladders of six pigs. Through cholecystostomy catheters, methyl tertiary-butyl ether (MTBE) was infused from 3 to 5 days. MTBE successfully dissolved 19 of the 20 cholesterol stones and partially dissolved one mixed cholesterol-bilirubin stone. Gross and microscopic examination of abdominal organs revealed mild superficial ulcerations of the gallbladder and mild to moderate chronic inflammatory changes in the gallbladder of animals treated with MTBE infusion. There were no other significant changes within other abdominal organs except for mild inflammation of the duodenum in one animal and of the common bile duct in another. Because of its efficacy and limited deleterious effects, MTBE may be a good solvent when dissolving pure cholesterol gallstones in the gallbladder.

AB - Human gallstones were surgically implanted in the gallbladders of six pigs. Through cholecystostomy catheters, methyl tertiary-butyl ether (MTBE) was infused from 3 to 5 days. MTBE successfully dissolved 19 of the 20 cholesterol stones and partially dissolved one mixed cholesterol-bilirubin stone. Gross and microscopic examination of abdominal organs revealed mild superficial ulcerations of the gallbladder and mild to moderate chronic inflammatory changes in the gallbladder of animals treated with MTBE infusion. There were no other significant changes within other abdominal organs except for mild inflammation of the duodenum in one animal and of the common bile duct in another. Because of its efficacy and limited deleterious effects, MTBE may be a good solvent when dissolving pure cholesterol gallstones in the gallbladder.

UR - http://www.scopus.com/inward/record.url?scp=0023724378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023724378&partnerID=8YFLogxK

M3 - Article

C2 - 3417437

AN - SCOPUS:0023724378

VL - 23

SP - 599

EP - 603

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 8

ER -