Dissolution of gallstones using cholecystostomy tube in the pig

John P McGahan, L. L. Lee, H. Tesluk, T. G. Nyland, B. Ruebner, B. Schmidt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H2O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbaldder irritation.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalInvestigative Radiology
Volume22
Issue number3
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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