Dissolution of gallstones using cholecystostomy tube in the pig

John P McGahan; L. L. Lee; H. Tesluk; T. G. Nyland; B. Ruebner; B. Schmidt

doi:10.1097/00004424-198703000-00003

Dissolution of gallstones using cholecystostomy tube in the pig

John P McGahan, L. L. Lee, H. Tesluk, T. G. Nyland, B. Ruebner, B. Schmidt

Radiology

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5 Scopus citations

Abstract

Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H₂O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbaldder irritation.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	Investigative Radiology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1097/00004424-198703000-00003
State	Published - 1987

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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abstract = "Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H2O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbaldder irritation.",

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AU - McGahan, John P

AU - Lee, L. L.

AU - Tesluk, H.

AU - Nyland, T. G.

AU - Ruebner, B.

AU - Schmidt, B.

PY - 1987

Y1 - 1987

N2 - Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H2O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbaldder irritation.

AB - Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H2O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbaldder irritation.

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Dissolution of gallstones using cholecystostomy tube in the pig

Abstract

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