Dissolution of cholesterol gallstones: Comparison of solvents

Lester L. Lee; John P McGahan

doi:10.1007/BF02035062

Dissolution of cholesterol gallstones: Comparison of solvents

Lester L. Lee, John P McGahan

Radiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Various gallstone solvents are compared to evaluate their efficacy. Cholesterol gallstones from 5 patients were weight matched and incubated in 5 different solutions at 37° C. These solutions consisted of methyl-tertiary butyl ether (MTBE), 90% mono-octanoin (MO), absolute alcohol, normal saline, and water. Absolute alcohol and MTBE were found to induce faster stone dissolution than the mono-octanoin derivative. Concentrations of alcohol below 80%, normal saline, and water were not effective in dissolving stones. Newer agents such as MTBE may prove valuable in dissolution of stones in the human gallbladder or bile ducts.

Original language	English (US)
Pages (from-to)	169-171
Number of pages	3
Journal	Gastrointestinal Radiology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/BF02035062
State	Published - Jan 1986

Keywords

Biliary tract, calculi
Gallstones, effect of solvents

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Gastroenterology

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10.1007/BF02035062

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abstract = "Various gallstone solvents are compared to evaluate their efficacy. Cholesterol gallstones from 5 patients were weight matched and incubated in 5 different solutions at 37° C. These solutions consisted of methyl-tertiary butyl ether (MTBE), 90% mono-octanoin (MO), absolute alcohol, normal saline, and water. Absolute alcohol and MTBE were found to induce faster stone dissolution than the mono-octanoin derivative. Concentrations of alcohol below 80%, normal saline, and water were not effective in dissolving stones. Newer agents such as MTBE may prove valuable in dissolution of stones in the human gallbladder or bile ducts.",

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AU - McGahan, John P

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AB - Various gallstone solvents are compared to evaluate their efficacy. Cholesterol gallstones from 5 patients were weight matched and incubated in 5 different solutions at 37° C. These solutions consisted of methyl-tertiary butyl ether (MTBE), 90% mono-octanoin (MO), absolute alcohol, normal saline, and water. Absolute alcohol and MTBE were found to induce faster stone dissolution than the mono-octanoin derivative. Concentrations of alcohol below 80%, normal saline, and water were not effective in dissolving stones. Newer agents such as MTBE may prove valuable in dissolution of stones in the human gallbladder or bile ducts.

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KW - Gallstones, effect of solvents

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Dissolution of cholesterol gallstones: Comparison of solvents

Abstract

Keywords

ASJC Scopus subject areas

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