Dissociations of the Medial and Lateral Perforant Path Projections Into Dorsal DG, CA3, and CA1 for Spatial and Nonspatial (Visual Object) Information Processing

Michael R. Hunsaker, Graham G. Mooy, Jesse S. Swift, Raymond P. Kesner

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Medial perforant path plasticity can be attenuated by 2-amino-5-phosphonovaleric acid (APV) infusions, whereas lateral perforant path plasticity can be attenuated by naloxone infusions. The present experiment was designed to evaluate the role of each entorhinal efferent pathway into the dorsal hippocampus for detection of spatial and nonspatial (visual object) changes in the overall configuration of environmental stimuli. Dorsal dentate gyrus infusions of either APV or naloxone attenuated detection of a spatial change, whereas only naloxone infusions disrupted novel object detection. Either APV or naloxone infusions into dorsal CA3 disrupted both spatial and novel object detection. APV infusions into dorsal CA1 attenuated detection of a spatial change, whereas naloxone infusions into dorsal CA1 disrupted novel object detection. These data suggest that each dorsal hippocampal subregion processes spatial and nonspatial (visual object) information from perforant path efferents in a unique manner that is consistent with the intrinsic properties of each subregion.

Original languageEnglish (US)
Pages (from-to)742-750
Number of pages9
JournalBehavioral Neuroscience
Volume121
Issue number4
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Keywords

  • APV
  • hippocampus
  • naloxone
  • novelty detection
  • spatial exploration

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

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