Dissociation of infectivity and pathogenicity in Borrelia burgdorferi

V. Thomas, J. Anguita, S. Samanta, P. A. Rosa, P. Stewart, Stephen W Barthold, E. Fikrig

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B. burgdorferi cN40, N40-75, and N40-120 have distinct phenotypes that can he used to dissect the genetic elements responsible for pathogenicity and infectivity.

Original languageEnglish (US)
Pages (from-to)3507-3509
Number of pages3
JournalInfection and Immunity
Issue number5
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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