Dissociable dopamine dynamics for learning and motivation

Ali Mohebi, Jeffrey R. Pettibone, Arif A. Hamid, Jenny Marie T. Wong, Leah T. Vinson, Tommaso Patriarchi, Lin Tian, Robert T. Kennedy, Joshua D. Berke

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is critical for motivation to work for rewards and reward-driven learning. How dopamine supports both functions is unclear. Dopamine cell spiking can encode prediction errors, which are vital learning signals in computational theories of adaptive behaviour. By contrast, dopamine release ramps up as animals approach rewards, mirroring reward expectation. This mismatch might reflect differences in behavioural tasks, slower changes in dopamine cell spiking or spike-independent modulation of dopamine release. Here we compare spiking of identified VTA dopamine cells with NAc dopamine release in the same decision-making task. Cues that indicate an upcoming reward increased both spiking and release. However, NAc core dopamine release also covaried with dynamically evolving reward expectations, without corresponding changes in VTA dopamine cell spiking. Our results suggest a fundamental difference in how dopamine release is regulated to achieve distinct functions: broadcast burst signals promote learning, whereas local control drives motivation.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalNature
Volume570
Issue number7759
DOIs
StatePublished - Jun 6 2019

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Motivation
Dopamine
Learning
Reward
Ventral Tegmental Area
Nucleus Accumbens
Architectural Accessibility
Psychological Adaptation
Cell Nucleus
Cues
Decision Making

ASJC Scopus subject areas

  • General

Cite this

Mohebi, A., Pettibone, J. R., Hamid, A. A., Wong, J. M. T., Vinson, L. T., Patriarchi, T., ... Berke, J. D. (2019). Dissociable dopamine dynamics for learning and motivation. Nature, 570(7759), 65-70. https://doi.org/10.1038/s41586-019-1235-y

Dissociable dopamine dynamics for learning and motivation. / Mohebi, Ali; Pettibone, Jeffrey R.; Hamid, Arif A.; Wong, Jenny Marie T.; Vinson, Leah T.; Patriarchi, Tommaso; Tian, Lin; Kennedy, Robert T.; Berke, Joshua D.

In: Nature, Vol. 570, No. 7759, 06.06.2019, p. 65-70.

Research output: Contribution to journalArticle

Mohebi, A, Pettibone, JR, Hamid, AA, Wong, JMT, Vinson, LT, Patriarchi, T, Tian, L, Kennedy, RT & Berke, JD 2019, 'Dissociable dopamine dynamics for learning and motivation', Nature, vol. 570, no. 7759, pp. 65-70. https://doi.org/10.1038/s41586-019-1235-y
Mohebi A, Pettibone JR, Hamid AA, Wong JMT, Vinson LT, Patriarchi T et al. Dissociable dopamine dynamics for learning and motivation. Nature. 2019 Jun 6;570(7759):65-70. https://doi.org/10.1038/s41586-019-1235-y
Mohebi, Ali ; Pettibone, Jeffrey R. ; Hamid, Arif A. ; Wong, Jenny Marie T. ; Vinson, Leah T. ; Patriarchi, Tommaso ; Tian, Lin ; Kennedy, Robert T. ; Berke, Joshua D. / Dissociable dopamine dynamics for learning and motivation. In: Nature. 2019 ; Vol. 570, No. 7759. pp. 65-70.
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