Dissociable correlates of recollection and familiarity within the medial temporal lobes

Charan Ranganath, Andrew P. Yonelinas, Michael X. Cohen, Christine J. Dy, Sabrina M. Tom, Mark D'Esposito

Research output: Contribution to journalArticle

489 Citations (Scopus)

Abstract

Regions in the medial temporal lobes (MTL) have long been implicated in the formation of new memories for events, however, it is unclear whether different MTL subregions support different memory processes. Here, we used event-related functional magnetic resonance imaging (fMRI) to examine the degree to which two recognition memory processes - recollection and familiarity - were supported by different MTL subregions. Results showed that encoding activity in the rhinal cortex selectively predicted familiarity-based recognition, whereas, activity in the hippocampus and posterior parahippocampal cortex selectively predicted recollection. Collectively, these results support the view that different subregions within the MTL memory system implement unique encoding processes that differentially support familiarity and recollection.

Original languageEnglish (US)
Pages (from-to)2-13
Number of pages12
JournalNeuropsychologia
Volume42
Issue number1
DOIs
StatePublished - 2004

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Temporal Lobe
Nose
Hippocampus
Magnetic Resonance Imaging
Recognition (Psychology)

Keywords

  • Encoding
  • Episodic
  • fMRI
  • Frontal
  • Hippocampus
  • Human
  • Inferior
  • Long-term
  • Medial
  • Memory
  • Neuroimaging
  • Parahippocampal
  • Perirhinal
  • Prefrontal
  • Rhinal
  • Subsequent
  • Temporal

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Ranganath, C., Yonelinas, A. P., Cohen, M. X., Dy, C. J., Tom, S. M., & D'Esposito, M. (2004). Dissociable correlates of recollection and familiarity within the medial temporal lobes. Neuropsychologia, 42(1), 2-13. https://doi.org/10.1016/j.neuropsychologia.2003.07.006

Dissociable correlates of recollection and familiarity within the medial temporal lobes. / Ranganath, Charan; Yonelinas, Andrew P.; Cohen, Michael X.; Dy, Christine J.; Tom, Sabrina M.; D'Esposito, Mark.

In: Neuropsychologia, Vol. 42, No. 1, 2004, p. 2-13.

Research output: Contribution to journalArticle

Ranganath, C, Yonelinas, AP, Cohen, MX, Dy, CJ, Tom, SM & D'Esposito, M 2004, 'Dissociable correlates of recollection and familiarity within the medial temporal lobes', Neuropsychologia, vol. 42, no. 1, pp. 2-13. https://doi.org/10.1016/j.neuropsychologia.2003.07.006
Ranganath, Charan ; Yonelinas, Andrew P. ; Cohen, Michael X. ; Dy, Christine J. ; Tom, Sabrina M. ; D'Esposito, Mark. / Dissociable correlates of recollection and familiarity within the medial temporal lobes. In: Neuropsychologia. 2004 ; Vol. 42, No. 1. pp. 2-13.
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