Disseminated infections with antibiotic-resistant non-typhoidal Salmonella strains: contributions of host and pathogen factors

Kristen L. Lokken, Gregory T. Walker, Renee M Tsolis

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Non-typhoidal Salmonella enterica serovars (NTS) are generally associated with gastroenteritis; however, the very young and elderly, as well as individuals with compromised immunity, are at risk of developing disseminated infection that can manifest as bacteremia or focal infections at systemic sites. Disseminated NTS infections can be fatal and are responsible for over 600 000 deaths annually. Most of these deaths are in sub-Saharan Africa, where multidrug-resistant NTS clones are currently circulating in a population with a high proportion of individuals that are susceptible to disseminated disease. This review considers how genome degradation observed in African NTS isolates has resulted in phenotypic differences in traits related to environmental persistence and host-pathogen interactions. Further, it discusses host mechanisms promoting susceptibility to invasive infection with NTS in individuals with immunocompromising conditions. We conclude that mechanistic knowledge of how risk factors compromise immunity to disseminated NTS infection will be important for the design of interventions to protect against systemic disease.

Original languageEnglish (US)
JournalPathogens and Disease
Volume74
Issue number8
StatePublished - Nov 1 2016

Keywords

  • bacteremia
  • co-infection
  • malaria
  • Salmonella

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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