Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation

J. S H Gaston, S. Strober, J. J. Solovera, D. Gandour, Nancy E Lane, D. Schurman, R. T. Hoppe, R. C. Chin, E. M. Eugui, J. H. Vaughan, A. C. Allison

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalArthritis and Rheumatism
Volume31
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Lymphatic Irradiation
Dissection
Rheumatoid Arthritis
Joint Diseases
Rheumatoid Factor
Synovial Fluid
Wounds and Injuries
Interleukin-1
Immunoglobulin A
Immunoglobulin M
Radiotherapy
Immunoglobulin G
T-Lymphocytes
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Gaston, J. S. H., Strober, S., Solovera, J. J., Gandour, D., Lane, N. E., Schurman, D., ... Allison, A. C. (1988). Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation. Arthritis and Rheumatism, 31(1), 21-30.

Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation. / Gaston, J. S H; Strober, S.; Solovera, J. J.; Gandour, D.; Lane, Nancy E; Schurman, D.; Hoppe, R. T.; Chin, R. C.; Eugui, E. M.; Vaughan, J. H.; Allison, A. C.

In: Arthritis and Rheumatism, Vol. 31, No. 1, 1988, p. 21-30.

Research output: Contribution to journalArticle

Gaston, JSH, Strober, S, Solovera, JJ, Gandour, D, Lane, NE, Schurman, D, Hoppe, RT, Chin, RC, Eugui, EM, Vaughan, JH & Allison, AC 1988, 'Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation', Arthritis and Rheumatism, vol. 31, no. 1, pp. 21-30.
Gaston, J. S H ; Strober, S. ; Solovera, J. J. ; Gandour, D. ; Lane, Nancy E ; Schurman, D. ; Hoppe, R. T. ; Chin, R. C. ; Eugui, E. M. ; Vaughan, J. H. ; Allison, A. C. / Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation. In: Arthritis and Rheumatism. 1988 ; Vol. 31, No. 1. pp. 21-30.
@article{469b63ce7617429aa8a426a56943906a,
title = "Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation",
abstract = "Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.",
author = "Gaston, {J. S H} and S. Strober and Solovera, {J. J.} and D. Gandour and Lane, {Nancy E} and D. Schurman and Hoppe, {R. T.} and Chin, {R. C.} and Eugui, {E. M.} and Vaughan, {J. H.} and Allison, {A. C.}",
year = "1988",
language = "English (US)",
volume = "31",
pages = "21--30",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation

AU - Gaston, J. S H

AU - Strober, S.

AU - Solovera, J. J.

AU - Gandour, D.

AU - Lane, Nancy E

AU - Schurman, D.

AU - Hoppe, R. T.

AU - Chin, R. C.

AU - Eugui, E. M.

AU - Vaughan, J. H.

AU - Allison, A. C.

PY - 1988

Y1 - 1988

N2 - Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

AB - Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

UR - http://www.scopus.com/inward/record.url?scp=0023860823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023860823&partnerID=8YFLogxK

M3 - Article

C2 - 3257873

AN - SCOPUS:0023860823

VL - 31

SP - 21

EP - 30

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 1

ER -