Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation

J. S H Gaston, S. Strober, J. J. Solovera, D. Gandour, Nancy E Lane, D. Schurman, R. T. Hoppe, R. C. Chin, E. M. Eugui, J. H. Vaughan, A. C. Allison

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalArthritis and Rheumatism
Volume31
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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    Gaston, J. S. H., Strober, S., Solovera, J. J., Gandour, D., Lane, N. E., Schurman, D., Hoppe, R. T., Chin, R. C., Eugui, E. M., Vaughan, J. H., & Allison, A. C. (1988). Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation. Arthritis and Rheumatism, 31(1), 21-30.