Abstract
The composition of human milk is tailored to contribute to the development of the gastrointestinal (GI) tract of newborns and infants. Importantly, human milk contains the antimicrobial compounds lysozyme and lactoferrin that are thought to contribute to the formation of a health-promoting microbiota. As these protective factors are lacking in the milk of dairy animals, we genetically engineered goats expressing human lysozyme in their milk and have recently reported a new animal model to dissect out the role of milk components on gut microbiota formation. Using the pig as a more human-relevant animal model, we demonstrated that consumption of lysozyme-rich milk enriched the abundance of bacteria associated with GI health and decreased those associated with disease, much like human milk. This work demonstrated that the pig is a valid animal model for gut microbiome studies on the effects of dietary components on microbiota composition, host-microbe interactions and state of the intestine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 136-139 |
| Number of pages | 4 |
| Journal | Gut Microbes |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2013 |
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Keywords
- Gut microbiota
- Intestine
- Lysozyme
- Pig model
- Transgenic
ASJC Scopus subject areas
- Gastroenterology
- Infectious Diseases
- Microbiology (medical)
- Microbiology
Cite this
Dissecting the role of milk components on gut microbiota composition. / Maga, Elizabeth A.; Weimer, Bart C; Murray, James D.
In: Gut Microbes, Vol. 4, No. 2, 03.2013, p. 136-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dissecting the role of milk components on gut microbiota composition
AU - Maga, Elizabeth A.
AU - Weimer, Bart C
AU - Murray, James D.
PY - 2013/3
Y1 - 2013/3
N2 - The composition of human milk is tailored to contribute to the development of the gastrointestinal (GI) tract of newborns and infants. Importantly, human milk contains the antimicrobial compounds lysozyme and lactoferrin that are thought to contribute to the formation of a health-promoting microbiota. As these protective factors are lacking in the milk of dairy animals, we genetically engineered goats expressing human lysozyme in their milk and have recently reported a new animal model to dissect out the role of milk components on gut microbiota formation. Using the pig as a more human-relevant animal model, we demonstrated that consumption of lysozyme-rich milk enriched the abundance of bacteria associated with GI health and decreased those associated with disease, much like human milk. This work demonstrated that the pig is a valid animal model for gut microbiome studies on the effects of dietary components on microbiota composition, host-microbe interactions and state of the intestine.
AB - The composition of human milk is tailored to contribute to the development of the gastrointestinal (GI) tract of newborns and infants. Importantly, human milk contains the antimicrobial compounds lysozyme and lactoferrin that are thought to contribute to the formation of a health-promoting microbiota. As these protective factors are lacking in the milk of dairy animals, we genetically engineered goats expressing human lysozyme in their milk and have recently reported a new animal model to dissect out the role of milk components on gut microbiota formation. Using the pig as a more human-relevant animal model, we demonstrated that consumption of lysozyme-rich milk enriched the abundance of bacteria associated with GI health and decreased those associated with disease, much like human milk. This work demonstrated that the pig is a valid animal model for gut microbiome studies on the effects of dietary components on microbiota composition, host-microbe interactions and state of the intestine.
KW - Gut microbiota
KW - Intestine
KW - Lysozyme
KW - Pig model
KW - Transgenic
UR - http://www.scopus.com/inward/record.url?scp=84874733585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874733585&partnerID=8YFLogxK
U2 - 10.4161/gmic.23188
DO - 10.4161/gmic.23188
M3 - Article
C2 - 23235404
AN - SCOPUS:84874733585
VL - 4
SP - 136
EP - 139
JO - Gut Microbes
JF - Gut Microbes
SN - 1949-0976
IS - 2
ER -