Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors

Hashmat Sikder, David L. Huso, Hong Zhang, Binghe Wang, Byungwoo Ryu, Samuel T Hwang, Jonathan D. Powell, Rhoda M. Alani

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Id genes regulate tumor angiogenesis and loss of Id1 inhibits tumor xenograft growth in mice. Here we evaluate the role of Id1 in a more clinically relevant tumor model system using a two-step chemical carcinogenesis protocol. Remarkably, we find that Id1-/- mice are more susceptible to skin tumorigenesis compared to their wild-type counterparts. Cutaneous neoplasms in Id1-/- mice show increased proliferation without alterations in tumor angiogenesis; however, Id1-/- mice possess 50% fewer cutaneous γδ T cells than their wild-type counterparts due to an intrinsic migration defect associated with loss of expression of the chemokine receptor, CXCR4. We suggest that there are important differences between the mechanisms of angiogenesis in transplanted and autochthonous tumors and that these findings will have significant implications for the potential utility of antiangiogenic therapies in cancer.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalCancer Cell
Volume4
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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