Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder

Michael J. Minzenberg, Glenn C. Gomes, Jong H. Yoon, Tamara Y. Swaab, Cameron S Carter

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Schizophrenia patients experience cognitive control disturbances, manifest in altered neural signatures during action monitoring. It remains unclear whether error- and conflict-monitoring disturbances co-occur, and whether they are observed in recent-onset psychosis patients with schizophrenia or bipolar disorder. We tested electrophysiological measures of action monitoring in these patients. Seventy-three schizophrenia patients (SZ), 26 bipolar disorder type I patients (BP), each within one year of psychosis onset, and 54 healthy control subjects (HC) underwent EEG during Stroop task performance. In the trial-averaged EEG at three midline scalp electrodes, the error-related negativity (ERN), error positivity (Pe) and conflict-related N450 were measured. Compared to HC (1) SZ exhibited an attenuated ERN and N450, and Pe unchanged and (2) BP exhibited an attenuated ERN but normal Pe and N450. Between patient groups, SZ showed an attenuated N450; ERN and Pe were not significantly different. A small (n=10) SZ subgroup that was not receiving antipsychotic medication showed normal ERPs. Altered error- and conflict-monitoring occur together in the first-episode schizophrenia patients, and these measures are comparable in patients with the first-episode bipolar disorder. Antipsychotic medication may be associated with altered measures of error-monitoring in schizophrenia.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume221
Issue number1
DOIs
StatePublished - Jan 30 2014

Keywords

  • Conflict
  • Error positivity
  • Error-related negativity
  • N450
  • Performance adjustment
  • Stroop

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Fingerprint Dive into the research topics of 'Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder'. Together they form a unique fingerprint.

  • Cite this