Abstract
The disposition kinetics of propofoi have been determined in 12 patients (six female) receiving propof of 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofoi concentrations determined by HPL C with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program EL SFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss: Vγ ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309min(60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofoi concentration associated with recovery from anaesthesia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1075-1079 |
| Number of pages | 5 |
| Journal | British Journal of Anaesthesia |
| Volume | 58 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Anesthesiology and Pain Medicine
Cite this
Disposition of propofol in patients undergoing surgery : A comparison in men and women. / Kay, N. H.; Sear, J. W.; Uppington, Jeffrey; Cockshott, I. D.; Douglas, E. J.
In: British Journal of Anaesthesia, Vol. 58, No. 10, 10.1986, p. 1075-1079.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disposition of propofol in patients undergoing surgery
T2 - A comparison in men and women
AU - Kay, N. H.
AU - Sear, J. W.
AU - Uppington, Jeffrey
AU - Cockshott, I. D.
AU - Douglas, E. J.
PY - 1986/10
Y1 - 1986/10
N2 - The disposition kinetics of propofoi have been determined in 12 patients (six female) receiving propof of 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofoi concentrations determined by HPL C with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program EL SFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss: Vγ ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309min(60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofoi concentration associated with recovery from anaesthesia.
AB - The disposition kinetics of propofoi have been determined in 12 patients (six female) receiving propof of 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofoi concentrations determined by HPL C with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program EL SFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss: Vγ ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309min(60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofoi concentration associated with recovery from anaesthesia.
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U2 - 10.1093/bja/58.10.1075
DO - 10.1093/bja/58.10.1075
M3 - Article
VL - 58
SP - 1075
EP - 1079
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
SN - 0007-0912
IS - 10
ER -